Improvement in Aerobic Capacity After an Exercise Program in Sporadic Inclusion Body Myositis

Johnson, Liam; Collier, Kelly E; Edwards, Dylan; Philippe, Danielle L.; Eastwood, Peter R.; Walters, Sue; Thickbroom, Gary; Mastaglia, Frank

doi:10.1097/cnd.0b013e3181a23c86

Cited by 91 publications

(79 citation statements)

References 28 publications

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“…Indirectly, it may suggest that physical activity could be achievable and efficient in sIBM patients. Actually, a recent study showed that an aerobic exercise program could improve muscle strength in such patients [16].…”

Section: Discussionmentioning

confidence: 99%

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Allenbach¹,

Benveniste²,

Decostre³

et al. 2012

Neuromuscular Disorders

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Section: Discussionmentioning

confidence: 99%

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Allenbach¹,

Benveniste²,

Decostre³

et al. 2012

Neuromuscular Disorders

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“…Additionally supporting its distinction from PM/DM is the fact that IBM exhibits little response to immunosuppressive therapy [8•, 13-17]. Although there is some modest evidence of the benefit of exercise, IBM is an inexorably progressive disease [7,18,19]. The majority of patients require some type of assistive device for ambulation within 10 years of symptom onset, and many patients eventually require a wheelchair for mobility.…”

Section: Inclusion Body Myositismentioning

confidence: 97%

Myositis Mimics

Michelle

Mammen

2015

Curr Rheumatol Rep

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Patients with autoimmune myositis typically present with muscle weakness, elevated serum levels of muscle enzymes, and abnormal muscle biopsies. However, patients with other acquired myopathies or genetic muscle diseases may have remarkably similar presentations. Making the correct diagnosis of another muscle disease can prevent these patients from being exposed to the risks of immunosuppressive medications, which benefit those with myositis, but not those with other types of muscle disease. Here, we review some of the most common acquired and inherited muscle diseases that can mimic autoimmune myositis, including inclusion body myositis, limb girdle muscular dystrophies, metabolic myopathies, mitochondrial myopathies, and endocrine myopathies. We emphasize aspects of the medical history, physical exam, laboratory evaluation, and muscle biopsy analysis that can help clinicians distinguish myositis mimics from true autoimmune myositis.

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“…It has been shown in small short-term trials that individualised exercise programs can lead to improvement or maintenance of muscle strength and aerobic capacity, as well as improved quality of life (Johnson et al, 2007, Johnson et al, 2009). However, further investigation is needed to determine the most effective exercise protocols and to establish guidelines for their use in IBM patients.…”

Section: Treatmentmentioning

confidence: 99%

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

Needham

Mastaglia

2016

Clinical Neurophysiology

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Sporadic inclusion body myositis is the most frequent acquired myopathy of middle and later life and is distinguished from other inflammatory myopathies by its selective pattern of muscle involvement and slowly progressive course, and by the combination of inflammatory and degenerative muscle pathology and multi-protein deposits in muscle tissue. This review summarises the findings of recent studies that provide a more complete picture of the clinical phenotype and natural history of the disease and its global prevalence and genetic predisposition. Current diagnostic criteria, including the role of electrophysiological and muscle imaging studies and the recently identified anti-5'-nucleotidase (anti-cN1A) antibody in diagnosis are also discussed as well as current trends in the treatment of the disease.

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Improvement in Aerobic Capacity After an Exercise Program in Sporadic Inclusion Body Myositis

Cited by 91 publications

References 28 publications

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Quadriceps strength is a sensitive marker of disease progression in sporadic inclusion body myositis

Myositis Mimics

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

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