Improvement in adherence to Capecitabine and Lapatinib by way of a therapeutic education program

Interpersonal communication-, education- and counselling-based interventions to support adherence to oral anticancer therapy: a systematic review

“…Among the 24 included studies, 13 were based in North America (all in the United States), 6,[23][24][25][26][27][28][29][30][31][32][33][34] 6 in Europe, [35][36][37][38][39][40] 4 in Asia, [41][42][43][44] and one in Africa 45 (Table 1). Among the 22 studies that reported the type of malignancies studied, nine included patients with solid tumours only, 24,26,36,37,39,40,[43][44][45] five included patients with hematological malignancies only (all chronic myeloid leukemia [CML]), 27,32,35,41,42 and eight included patients with either a solid or hematological malignancy. 6,23,[28][29][30][31]34,38 While the sample size of these studies ranged from 33 to 928, the majority (n = 15) included less than ...…”

“…As indicated in Table 1, patients' medication taking between these two time points was measured using various data sources, including patient self-reports (n = 6), 24,31,33,35,43,44 pharmacy fill records (n = 5), 26,27,32,34,38 and electronic pill caps (n = 4). 37,[39][40][41] Other studies relied solely on information obtained from electronic health records (n = 2). 28,29 Some studies used a combination of data sources, such as self-reports combined with pharmacy fill records (n = 2) 23,30 or pill counts (n = 2), 6,45 or a combination of patient self-reports and provider reports.…”

“…Fourteen of the papers 6,23,25,27,[29][30][31][32]34,[38][39][40]43,45 detailed some sort of pharmacist-based programme, five a nursebased programme, 24,33,35,42,44 and one that used a combination of nurses and pharmacists. 26 (Table 2) All papers described the intervention as addressing the management of side effects.…”

“…More than half of the programme descriptions referenced providing written educational materials, 6,[23][24][25][26]28,30,31,[34][35][36][37][38][39][40]42,44 and medication storage and handling information. 6,[29][30][31][32][33][38][39][40][41][42][43][44] Less commonly reported was guidance regarding concomitant medication management, 25,31,37,38,41,44 possible drug/drug or drug/food interactions, 6,25,27,31,37,38,41,44 and plans for missed doses. 6,27,30,37,40,44,…”

“…6,[29][30][31][32][33][38][39][40][41][42][43][44] Less commonly reported was guidance regarding concomitant medication management, 25,31,37,38,41,44 possible drug/drug or drug/food interactions, 6,25,27,31,37,38,41,44 and plans for missed doses. 6,27,30,37,40,44,45 The provision of referrals to other supportive programming 23,27,34 or guidance regarding financial assistance [28][29][30]34 was infrequently noted as being provided.…”