Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions

Rajneesh, Chellappan Praveen; Lai, Chien Hung; Chen, Shih Ching; Hsieh, Tsung Hsun; Chin, Hung Yen; Peng, Chih‐Wei

doi:10.1007/s11255-018-2028-1

Cited by 9 publications

(30 citation statements)

References 51 publications

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“…With a TBI, this area might have been severely damaged; hence, urine might not be properly evacuated, which would be a reason for the increased amount of RV. Furthermore, a similar condition was observed in spinal cord injury patients, and the reason was postulated as an increased RV due to upper urinary tract dilation and renal insufficiency [23].…”

Section: Discussionmentioning

confidence: 85%

“…As mentioned earlier, the absence of coordination between external urethral relaxation and detrusor contraction leads to intact sphincter tone. Urinary retention was sustained until larger bladder volumes were attained, and after reaching a certain level, bladder pressure and bladder wall stress subdued the barrier to maintain the urinary flow that was produced by the sphincter muscle [23]. In due course, the presence of a large bladder with improper sphincter tone increased the ICI value.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, this study has the same limitations as our previous study [23] since the WDM has been standardized in our laboratory, and it was used instead of the lateral fluid percussion impact (LFPI) model. However, the LFPI model rapidly induces severe and transient lower urinary tract dysfunction, and the WDM was chosen because of the favorable results of the MRI showing significant brain damage over the cerebral cortex area in both studies.…”

Section: Discussionmentioning

confidence: 99%

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Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study

et al. 2019

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Traumatic brain injuries (TBIs) are a serious public health issue worldwide with increased mortality as well as severe disabilities and injuries caused by falls and road accidents. Unfortunately, there is no approved therapy for TBIs, and bladder dysfunction is a striking symptom. Accordingly, we attempted to analyze bladder dysfunction and voiding efficiency in rats with a TBI at different time-course intervals. Time-dependent analyses were scheduled from the next day until four weeks after a TBI. Experimental animals were grouped and analyzed under the above conditions. Cystometric measurements were used for this analysis and were further elaborated as external urethral sphincter electromyographic (EUS-EMG) activity and cystometrogram (CMG) measurements. Moreover, magnetic resonance imaging (MRI) studies were conducted to investigate secondary injury progression in TBI rats, and results were compared to normal control (NC) rats. Results of EUS-EMG revealed that the burst period, active period, and silent period in TBI rats were drastically reduced compared to NC rats, but they increased later and reached a stagnant phase. Likewise, in CMG measurements, bladder function, the voided volume, and voiding efficiency decreased immediately after the TBI, and other parameters like the volume threshold, inter-contraction interval, and residual volume drastically increased. Later, those levels changed, and all observed results were compared to NC rats. MRI results revealed the prevalence of cerebral edema and the progression of secondary injury. All of the above-stated results of the experiments were extensively substantiated. Thus, these innovative findings of our study model will surely pave the way for new therapeutic interventions for TBI treatment and prominently highlight their applications in the field of neuroscience in the future.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study

et al. 2019

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“…For comparison between our wireless biomicrosystem and a standard clinical diagnostic procedure, we compared the bladder pressures measured by this device and cystometric measurements with a commercial biological signal acquisition system (Biopac MP 36, BIOPAC Systems, Santa Barbara, CA, USA). Cystometry was performed the same way as in our previous studies [ 21 , 22 , 23 ]. The rabbit was anesthetized with isoflurane (3~5%) through a facemask.…”

Section: Methodsmentioning

confidence: 99%

Designing and Implementing an Implantable Wireless Micromanometer System for Real-Time Bladder Pressure Monitoring: A Preliminary Study

Yang

Hsu

et al. 2020

Sensors

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Many mini-implantable devices have been developed and fabricated for diagnostic and treatment purposes. Wireless implantable biomicrosystems provide a desirable approach for long-term physiological signal monitoring. In this study, we implemented a wireless implantable biomicrosystem for bladder-cavity pressure measurements in a freely moving rabbit. To manage the power more effectively, a magnetic reed switch was applied to turn on/off the implantable module using a neodymium–iron–boron (NdFeB) magnet. The measured bladder pressure signal was wirelessly transmitted from the implantable module to a host unit. Our results indicated that the implantable biomicrosystem exhibited satisfactory performance and safety, as evidenced by an error percentage of less than ±1% for pressure measurements and less than 2 °C of a temperature rise under normal operation. The wireless biomicrosystem was implanted into the bladder cavity of a rabbit. Bladder pressure was simultaneously measured by both the biomicrosystem and conventional cystometry in the animal. The two signals were similar during the voiding phase, with a correlation coefficient of 0.885. Additionally, the biomicrosystem coated with polydimethylsiloxane in this study showed no cytotoxicity, which confirmed its biocompatibility. In conclusion, we demonstrated a good biocompatible wireless biomicrosystem which showed good reproducibility with respect to pressure monitoring by conventional cystometry. Further studies are needed to confirm the results of this preliminary feasibility study for actual clinical applications.

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“…In the brain, the PMC facilitates storage and micturition according to signals it receives from the periaqueductal gray (PAG). Excitation of the PMC triggers descending pathways that initiate urethral relaxation, and within a few seconds, the sacral parasympathetic outflow is activated [32].…”

Section: Plos Onementioning

confidence: 99%

The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections

et al. 2020

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Bladder dysfunction is a common phenomenon in Parkinson’s disease (PD) patients. A research attempt was made to analyze the voiding efficiency (VE) and bladder functions in rats with PD induced by unilateral or bilateral injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. PD rats were divided into unilateral- and bilateral-injected groups and subjected to rotation and beam walking tests. Further, the experimental rats underwent cystometric measurements for analyses of bladder dysfunction and VE. Immunohistochemical analysis was performed to analyze the dopaminergic neuron depletion on the target area. Outcomes of the rotation and beam walking tests revealed the extent of parkinsonism in the experimental rats. Urodynamic observations denoted that rats with unilateral PD exhibited a significantly decreased VE (from 68.3±3.5% to 32.7±5.8%), while rats with bilateral PD displayed a much-reduced and substantially lower level of VE of 18.3±5.1% compared to the control value and to that of rats with unilateral PD. Rats with bilateral PD showed more-extensive behavioral deficits and urodynamic changes than did rats with unilateral PD. These significant changes in motor, behavioral, bladder function and VE were due to an extensive degeneration of dopaminergic neurons in the substantia nigra region on both sides of the brain. The obtained results were substantiated with appropriate immunohistochemical results.

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Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions

Cited by 9 publications

References 51 publications

Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study

Cystometric Measurements in Rats with an Experimentally Induced Traumatic Brain Injury and Voiding Dysfunction: A Time-Course Study

Designing and Implementing an Implantable Wireless Micromanometer System for Real-Time Bladder Pressure Monitoring: A Preliminary Study

The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections

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