Improved understanding of gene expression regulation using systems biology

Kuczenski, Robert S.; Aggarwal, Kunal; Lee, Kelvin H.

doi:10.1586/14789450.2.6.915

Cited by 5 publications

(6 citation statements)

References 84 publications

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“…A significant challenge in quantitative biology is that of developing productive collaborations that do not have the unrealistic requirement of at least one collaborator being an expert in everyone else's field (Kuczenski et al , 2005). Although such collaborations have been developed and have shown to be productive, it is not immediately apparent how students in disparate fields might be taught to collaborate productively even if each member has incomplete knowledge of the field(s) of their fellow collaborators.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, current efforts tend to focus on creating integrated, introductory curricula common to several majors (mathematics, biology, and computer science) that indicate how fundamental ideas in each discipline contribute to the understanding of the life sciences (Bialek and Botstein, 2004; Knisley et al , 2010; Moore et al , 2010). Researchers likewise tend to become conversant in other fields while remaining an expert in only one or two fields (Kuczenski et al , 2005). …”

Section: Introductionmentioning

confidence: 99%

“…Molecular biologists, for example, are partnering with computer scientists and mathematicians (Kuczenski et al , 2005), physicists are finding new uses for models once thought to be nonbiological (Rowlands, 1983), and the process of conducting clinical trials is being challenged by new trends in mathematics and statistics (Couzin, 2004). Moreover, both the successes and the failures of these collaborations can often be traced to their being distributed across several different locations, cultures, institutions, and disciplines (Hastings et al , 2003).…”

Section: Introductionmentioning

confidence: 99%

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Developing Student Collaborations across Disciplines, Distances, and Institutions

Knisley

Behravesh

2010

LSE

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Because quantitative biology requires skills and concepts from a disparate collection of different disciplines, the scientists of the near future will increasingly need to rely on collaborations to produce results. Correspondingly, students in disciplines impacted by quantitative biology will need to be taught how to create and engage in such collaborations. In response to this important curricular need, East Tennessee State University and Georgia Technological University/Emory University cooperated in an unprecedented curricular experiment in which theoretically oriented students at East Tennessee State designed biophysical models that were implemented and tested experimentally by biomedical engineers at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Technological University and Emory University. Implementing the collaborations between two institutions allowed an assessment of the student collaborations from before the groups of students had met for the first time until after they had finished their projects, thus providing insight about the formation and conduct of such collaborations that could not have been obtained otherwise.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developing Student Collaborations across Disciplines, Distances, and Institutions

Knisley

Behravesh

2010

LSE

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“…16,17 Gene expression information, in itself, is therefore not sufficient to fully elucidate the relationship between genome sequence, gene expression and cellular dynamics. 18,19 Furthermore, the common approach of many studies of looking for genetic polymorphic variation primarily within the promoter regions of genes showing differential RNA expression is a limited strategy.…”

Section: Gene Expression Studiesmentioning

confidence: 99%

Evidence for a genetic role in varicose veins and chronic venous insufficiency

2012

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There is a strong body of circumstantial evidence which implicates genetics in the aetiology and pathology of varicose veins and venous ulcer disease. The aim of this review is to consider the current knowledge of the genetic associations and the ways in which new genetic technologies may be applied to advancing our understanding of the cause and progression of these venous diseases. A number of publications have used a candidate gene approach to identify genes implicated in venous disease. Although these studies have opened up important new insights, there has been a general failure to replicate results in an independent cohort of patients. With our limited knowledge of the biological pathways involved in the pathogenesis of venous disease we are not in a strong position to formulate truly erudite a priori candidate gene hypothesis-directed studies. A genome-wide association study should therefore be considered to help further our understanding of the genetic basis of venous disease. Due to the large sample sizes required for discovery and validation, using the new generations of molecular technologies, it will be necessary to form collaborating groups in order to successfully advance the field of venous disease genetics.

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“…, 2008 ). This shift toward collaboration is most likely because modern research requires extensive specialization; scientists today are expected to be heavily specialized in one field while being conversant in other fields ( Kuczenski et al. , 2005 ; Labov et al.…”

Section: Introductionmentioning

confidence: 99%

External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs

Callahan

Peterson

Martinez‐Vaz

et al. 2022

LSE

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This study examines how the inclusion of structured external collaborations in course-based undergraduate research experiences (CUREs) affects learning outcomes. Students worked with faculty from an external institution to refine their hypotheses and discuss their data. In the collaborative CURE cohort, students had greater gains in learning outcomes compared with students in standard CUREs and no-CURE controls.

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Improved understanding of gene expression regulation using systems biology

Cited by 5 publications

References 84 publications

Developing Student Collaborations across Disciplines, Distances, and Institutions

Developing Student Collaborations across Disciplines, Distances, and Institutions

Evidence for a genetic role in varicose veins and chronic venous insufficiency

External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs

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