Improved trends of lung cancer mortality‐to‐incidence ratios in countries with high healthcare expenditure

Sung, Wen‐Wei; Au, Kwong-Kwok; Wu, Han‐Ru; Yu, Chih Teng; Wang, Yao‐Chen

doi:10.1111/1759-7714.13912

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…This analysis of trend captured the declines of MIR inversely associated with HDI. Association of HDI with MIR of leading cancers is already reported, such as breast cancer (Sharma, 2019) and lung cancer (Sung et al, 2021). To our knowledge, association of MIR of CUP and HDI has not been reported yet.…”

Section: Limitations Of the Studymentioning

confidence: 84%

Cancer of unknown primary ‐ incidence, mortality trend, and mortality‐to‐incidence ratio is associated with human development index in Central Serbia, 1999–2018: Evidence from the national cancer registry

Ignjatović

Stojanović

Milošević

et al. 2021

European J Cancer Care

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Objectives: The aim was to estimate the trend of incidence, mortality and mortalityto-incidence ratio (MIR) in Central Serbia in 1999-2018 and its possible association with the human development index (HDI).Methods: In this study, cancer of unknown primary (CUP) was included as C77-C80 codes. Trend analysis was performed in the Joinpoint Regression Programme version 4.8.0.1. HDI combines life expectancy, educational attainment and gross national income. HDI values for Serbia are extracted from the global bank site.Results: Joinpoint regression analysis of the age-standardised incidence rate of CUP showed a significantly increasing trend with annual percent change (APC) of 8.5% (95% confidence interval [CI] 3.0-14.3%) in males and 7.8% (95%CI 2.7-13.2) in females. The age-standardised mortality rate of CUP showed a significantly decreasing trend with APC of À1.7% (95%CI À2.8 to À0.5%) in males and À1.4% (95%CI À2.7 to À0.1%) in females. MIR showed a significantly decreasing trend with APC of À9.3% (95%CI -14.6 -À3.6%) in males and À7.1% (95%CI À10.5% to À4.2%) in females. The linear regression showed significant inverse association among HDI and the MIR of CUP in males (r 2 = 0.464, p = 0.002) and in females (r 2 = 0.612, p < 0.001).Conclusions: Decline of MIR was associated with HDI, suggesting that CUP prognosis follows socio-economic status.

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Section: Limitations Of the Studymentioning

confidence: 84%

Cancer of unknown primary ‐ incidence, mortality trend, and mortality‐to‐incidence ratio is associated with human development index in Central Serbia, 1999–2018: Evidence from the national cancer registry

Ignjatović

Stojanović

Milošević

et al. 2021

European J Cancer Care

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“…GDP was also positively associated with testicular cancer incidence but negatively associated with testicular cancer mortality 28 . In addition, total health expenditure/GDP was related to a decrease in the ratio of morbidity and mortality of cancers such as stomach and lung cancers, suggesting that the total health expenditure was directly proportional to GDP and inversely proportional to the cancer mortality rate 29 , 30 . The increase in GDP has also contributed to the implementation of cancer research in China.…”

Section: Discussionmentioning

confidence: 99%

Cancer trends and risk factors in China over the past 30 years (1990-2019)

Wu¹,

Zhang²,

Jin³

et al. 2023

J. Cancer

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Objective: We retrospectively studied cancer mortality and incidence in China from 1990 to 2019, investigated the cancer trends and risk factors, and analyzed the effects of Gross Domestic Product (GDP) on cancer mortality and incidence. Methods: Data was obtained in "Our world in data" in October 2022 to explore mortality rates of different cancers and their trends and the roles of cancer risk factors, including GDP, air pollution, etc. Results: Over the past 30 years, cancer had been China's second leading cause of death. Tracheal, bronchial, and lung cancers, with an annual growth rate of 6.5%, were the most frequently diagnosed cancers. The burden of different cancers changed as the mortality rate of cancer changed. The age-standardized cancer mortality rate had decreased by 19.0%; cancer deaths in all age groups had increased. While the number of cancer deaths in the elderly aged ≥70 did not increase distinctively, its percentage increased by 52.1% and 1.7% annually. The percentage of patients with new-onset cancer increased by 240% and 8.6% annually. For every USD 1,000 increase in GDP, cancer deaths decreased by 2.3/100,000. Tobacco, meat, and alcohol consumption and BMI had increased and were not conducive to the future control of cancer. Conclusions: We summarized the incidence and mortality of major cancers and their trends in China over the past 30 years and analyzed the effects of GDP and the roles of cancer risk factors. Overall GDP growth and effective control of air pollution reduced cancer mortality, while population aging, smoking, alcohol consumption, BMI increasing, and meat consumption brought challenges for cancer control.

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“…Due to the expense of the current screening tests and treatment options, the prognosis of NPCs might be linked to economic status. However, compared with cancers with more established or feasible screening strategies and more therapeutic options, the correlations between MIR and healthcare expenditure on NPC are not as significant as correlations with lung cancer, colorectal cancer, gastric cancer, and lip and oral cancer [ 16 , 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Mortality-to-Incidence Ratio for Nasopharyngeal Carcinoma Is Associated with Health Expenditure

Chen

et al. 2022

Healthcare

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Geographic and gender-specific disparity can be observed in nasopharyngeal carcinoma (NPC). While screening and more effective therapies, such as induction chemotherapy, could improve survival rates, they are costly. This study aims to explore the correlation between healthcare expenditure and the mortality-to-incidence ratio (MIR) in NPC. Data were obtained from the World Health Organization and the Global Cancer Observatory. The correlation was evaluated by Spearman’s rank correlation coefficient. Most new cases and deaths occur in Asia, and more males are affected than females. Our study shows that countries with higher MIRs have lower levels of health expenditure regardless of the NPC’s gender-specific incidence. Correspondingly, MIRs are all significantly negatively associated with current health expenditure (CHE) per capita and CHE as a percentage of gross domestic product (CHE/GDP) in both genders. CHE per capita and CHE/GDP have a significant impact on NPC outcomes. Moreover, economic status is a potential major factor in MIR differences between countries.

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Improved trends of lung cancer mortality‐to‐incidence ratios in countries with high healthcare expenditure

Cited by 6 publications

References 18 publications

Cancer of unknown primary ‐ incidence, mortality trend, and mortality‐to‐incidence ratio is associated with human development index in Central Serbia, 1999–2018: Evidence from the national cancer registry

Cancer of unknown primary ‐ incidence, mortality trend, and mortality‐to‐incidence ratio is associated with human development index in Central Serbia, 1999–2018: Evidence from the national cancer registry

Cancer trends and risk factors in China over the past 30 years (1990-2019)

Mortality-to-Incidence Ratio for Nasopharyngeal Carcinoma Is Associated with Health Expenditure

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