Improved Transdermal Delivery of Rabies Vaccine using Iontophoresis Coupled Microneedle Approach

Arshad, Muhammad Sohail; Hussain, Saad Abdulrahman; Zafar, Saman; Rana, Sadia Jafar; Ahmad, Nadia; Jalil, Najmusama Abdul; Ahmad, Zeeshan

doi:10.1007/s11095-023-03521-0

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…The combined application can induce a cooperative effect that improves the delivery efficacy of biological macromolecules. Arshad et al studied the transdermal delivery of rabies vaccines using ItP technology coupled with microneedle approaches [ 105 ]. This study demonstrated that the application of ItP in combination with microneedles provided a relatively potent immunogenic response over conventional intramuscular injection.…”

Section: Itp-based Approaches For Effective Intradermal Vaccinationmentioning

confidence: 99%

Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis

Hasan,

Khatun,

Kogure

2023

Pharmaceutics

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Messenger RNA (mRNA) vaccines against infectious diseases and for anticancer immunotherapy have garnered considerable attention. Currently, mRNA vaccines encapsulated in lipid nanoparticles are administrated via intramuscular injection using a needle. However, such administration is associated with pain, needle phobia, and lack of patient compliance. Furthermore, side effects such as fever and anaphylaxis associated with the lipid nanoparticle components are also serious problems. Therefore, noninvasive, painless administration of mRNA vaccines that do not contain other problematic components is highly desirable. Antigen-presenting cells reside in the epidermis and dermis, making the skin an attractive vaccination site. Iontophoresis (ItP) uses weak electric current applied to the skin surface and offers a noninvasive permeation technology that enables intradermal delivery of hydrophilic and ionic substances. ItP-mediated intradermal delivery of biological macromolecules has also been studied. Herein, we review the literature on the use of ItP technology for intradermal delivery of naked mRNA vaccines which is expected to overcome the challenges associated with mRNA vaccination. In addition to the physical mechanism, we discuss novel biological mechanisms of iontophoresis, particularly ItP-mediated opening of the skin barriers and the intracellular uptake pathway, and how the combined mechanisms can allow for effective intradermal delivery of mRNA vaccines.

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Section: Itp-based Approaches For Effective Intradermal Vaccinationmentioning

confidence: 99%

Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis

Hasan,

Khatun,

Kogure

2023

Pharmaceutics

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“…Although there have been some developed systems based on the combination of MNs with iontophoresis for enhanced transdermal drug delivery, these systems usually rely on external power supply and do not have the self‐powered property. [ 27–29 ] We believe that the design in this study will also prove useful and robust for treating other diseases, such as diabetes, via delivery of biological macromolecules or therapeutic NPs to deep skin sites, for local or systemic use.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Deep‐Seated Melanoma Therapy through Wearable Self‐Powered Microneedle Patch

Wang,

He,

Zhao

et al. 2023

Advanced Materials

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Effective treatment of deep‐seated tumors relies on enhanced drug penetration in transdermal drug delivery systems. While microneedles (MNs) and iontophoresis techniques have shown improved transdermal drug delivery efficiency, challenges such as skin elasticity, high electrical resistance of the stratum corneum, and external power supply requirements hinder their efficacy in treating deep‐seated tumors. In this study, a wearable, self‐powered MN patch that integrates a flexible triboelectric nanogenerator (F‐TENG) is presented, aimed at advancing deep‐seated tumor therapy. MNs are composed of water‐soluble materials mixed with negatively charged pH‐responsive nanoparticles (NPs) loaded with therapeutic drugs. The F‐TENG harnesses personal mechanical movements generate electrical energy. Leveraging the advantages of both MNs and F‐TENG, therapeutic NPs can penetrate deep skin locations upon MN patch insertion, releasing drugs rapidly in acidic tumor tissues. Owing to these features, a single administration of the integrated MN‐patch in a mouse model with deep‐seated melanoma exhibits superior therapeutic efficacy in inhibiting deep‐located tumor compared to using the MN‐patch alone, indicating promising potential for treating tumors at deep sites.

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