Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3
Shaoquan Shi,
Si Chen,
Bowei Liang
et al.
Abstract:Background
Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expanded with chemical defined medium have improved therapeutic consistency.
Methods
In the current study, we studied the MSC subpopulation composition and variation in different types and batches of MSC expansion medium with scRNA-seq a… Show more
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