Improved Synthesis of Oxazoline Under Microwave Irradiation

Synthesis of cyclic esters of N-toluenesulfonyl ?-aminophosphonic acid

“…It has been reported that certain reactions such as Diels-Alder [15,16], ethenoid [17], Claisen reaction [18], Fischer cyclization [19], synthesis of heterocycles [20], hydrolysis of esters [21,22], phosphoanhydride [23] and adenosine triphosphate formation [24], rapid hydrogenation [25], deprotection of benzyl esters [26], deacetylation of diacetates [27], Graebe-Ullmann synthesis [28], oxazoline formation [29,30], Knoevengel condensation [31], and aromatic ether formation [32,33] could be facilitated by microwave irradiation. However, to the best of our knowledge, no such application has been devised for the previously described Mannich-type reaction.…”

An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation

“…The reaction of carboxylic acids [12][13][14][15][16][17] or acid derivatives like ester [18][19][20][21][22] with 2-aminoethanol is the most common method for the synthesis of oxazolines. In addition, other substrates such as imidate hydrochlorides [23], N-(2-hydroxyethyl) amides [24][25][26][27][28][29], ortho esters [30], imino ether hydrochlorides [31], aldehydes [32][33][34][35][36][37] and nitriles [38][39][40][41][42][43][44][45][46] have been used to prepare the oxazolines. Despite the potential applications of the reported procedures in the synthesis of 2-oxazoline derivatives, some of them suffered from one or more shortcomings such as prolonged reaction times, expensive catalysts, hazardous reaction conditions, tedious work-up procedures and lack of general applicability.…”

An efficient synthesis of New chiral oxazolines

“…Some other methods, starting from amino alcohols *Corresponding authors. E-mail: m-chem41@guilan.ac.ir reaction with carboxylic acids [12], ortho esters [13], nitriles [14], iminoethers [15] and acyl benzotriazoles [16] have been reported. Other major synthetic methods start from β-hydroxy amides, with cyclisation attained with a number of reagents including Burgess , reagent [17], DAST [18], PPh 3 /DIAD [19] and immobilized p-toluensulfonylchloride/Et 3 N [20].…”