Improved synthesis of chalcones under ultrasound irradiation

Li, Ji‐Tai; Yang, Wenzhi; Wang, Shuxiang; Li, Shenghui; Li, Tong‐Shuang

doi:10.1016/s1350-4177(02)00079-2

Cited by 138 publications

(39 citation statements)

References 7 publications

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“…In the last two decades, sonochemical methods have become widely used in organic synthesis [45][46][47]. Nowadays, the ultrasonic irradiation technique has been employed, not only to decrease reaction times, but also to improve yields in a large variety of polyfunctionalized heterocycles.…”

Section: Open Accessmentioning

confidence: 99%

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

et al. 2013

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A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2-20 min) and good yields (65%-80%).

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Section: Open Accessmentioning

confidence: 99%

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

et al. 2013

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“…Use of solvents in organic reactions are toxic, expensive and considered to be harmful to environment as the disposal of such solvents is a serious threat to the nature. To overcome this problem, there is a need for eco-friendly alternatives like solvent free grinding reactions [3], microwave irradiation [4] and ultrasonic reactions [5].…”

Section: Introductionmentioning

confidence: 99%

An Efficient, Solvent Free Synthesis of Some Chalcone Derivatives and Their Biological Evaluation

Fathimunnisa¹,

Manikandan²,

Sivakumar³

2018

Asian J. Chem.

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A solvent free grinding approach was adopted for the synthesis of (E)-1-(2',4'-difluorobiphenyl-4-yl)-3-arylprop-2-en-1-one derivatives. The synthesized derivatives were characterized by elemental analysis, mass, IR and NMR spectrometry. The in vitro antimicrobial activity of the derivatives showed moderate to potent activities against the tested microbes. Molecular docking studies were performed to evaluate the anticancer activities.

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“…In general, chalcones were prepared by Claisen-Schmidt condensation of electrophilic substituted benzaldehyde with substituted acetophenone as nucleophile in the presence of bases such as NaOH, KOH, Ba(OH) 2 , LiOH, NaH, hydrotalcites, Zeolites, Na 2 CO 3 , K 2 CO 3 , magnesium t-butoxide, alumina, MgO, KF/natural phosphate, calcined NaNO 3 -natural phosphates, and piperidine. Chalcones are also prepared by ultrasonic vibration and microwave irradiation techniques [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Flavones From 2-Hydroxy Acetophenone and Aromatic Aldehyde Derivatives by Conventional Methods and Green Chemistry Approach

Patel

Shah

2017

Asian J Pharm Clin Res

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Objective: Flavones occupy a special place in the realm of natural and synthetic organic chemistry owing to their diversified biological activities. In this study, a series of chalcone derivatives were synthesized and after cyclization of chalcone to synthesized various substituted flavone derivatives (2A-2L). Methods:The reaction of 2-hydroxy acetophenone with substituted aromatic aldehydes produced chalcone by trituration (NaOH) and conventional methods (KOH/EtOH), which upon further cyclization with dimethyl sulfoxide/I 2 resulted to form flavone derivatives. Results:The purity of compounds was ascertained by melting point and thin-layer chromatography. The synthesized compounds have been characterized by mass, infrared, and 1 H nuclear magnetic resonance spectral analysis. Conclusion:Based on spectral data, it was proved that all synthesized chalcones and flavones derivatives meet the standard values of various spectral techniques and further it will be evaluated for pharmacological activities.

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Improved synthesis of chalcones under ultrasound irradiation

Abstract: Claisen-Schmidt condensation of acetophenone with aromatic aldehydes catalyzed by pulverized KOH and KF-Al2O3 results chalcones in 52-97% and 83-98% yields respectively in alcoholic solvent under ultrasound irradiation.

Cited by 138 publications

References 7 publications

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

An Efficient, Solvent Free Synthesis of Some Chalcone Derivatives and Their Biological Evaluation

Synthesis of Flavones From 2-Hydroxy Acetophenone and Aromatic Aldehyde Derivatives by Conventional Methods and Green Chemistry Approach

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