Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells

Maurya, Akhilendra Kumar; Vinayak, Manjula

doi:10.1007/s11626-018-0309-8

Cited by 5 publications

(2 citation statements)

References 54 publications

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“…However, a combined treatment with quercetin (80 µM) and lonidamine (5 µM) has yielded a stronger antiproliferative effect on the cells compared to individual treatments. Previous studies have reported relatively higher doses or longer durations of exposure for both compounds in order to obtain a significant cytotoxic activity on breast cancer cells (Maurya & Vinayak 2019, Morais-Santos et al 2013; however, some studies have reported a relatively lower dose for quercetin. For instance, Hanikoglu et al 2020 reported the IC 50 value of quercetin as 73.63 µM and Niazvand et al 2019 reported it as 73.8 µM, both after 24 h of incubation (Hanikoglu et al 2020, Niazvand et al 2019.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression

Ozkan

Bakar‐Ates

2020

An. Acad. Bras. Ciênc.

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Combination therapies are becoming increasingly important to develop an effective treatment in cancer. Lonidamine is frequently used in cancer treatment, but it's often preferred to be used in combination with other drugs because of its side effects. In the present study, the effi cacy of the combination of lonidamine with quercetin, a fl avonoid of natural origin, on human MCF-7 breast cancer cells was evaluated. The results showed that the combined use of the compounds signifi cantly increased cytotoxicity compared to administration alone (p<0.0001). In addition, while lonidamine induced a cell cycle arrest in the G2/M phase, administration of quercetin and its combination with lonidamine arrested the cell division at S point, indicating the synergistic strength of quercetin on cytotoxicity. The combination of quercetin and lonidamine signifi cantly induced apoptosis of MCF-7 cells (p<0.0001) and increased caspase levels (p<0.0001). In this study, the combination of quercetin and lonidamine has been evaluated for the fi rst time and the combination treatment decreased MMP-2/-9 mRNA expression more potently than the effects of the compounds alone. The results showed that lonidamine was more effective when combined with quercetin, and their combination may be a candidate for a novel strategy of treatment for breast cancer.

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Section: Discussionmentioning

confidence: 99%

Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression

Ozkan

Bakar‐Ates

2020

An. Acad. Bras. Ciênc.

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“…ese properties have been demonstrated through the increase of glutathione peroxidase (GSH), superoxide dismutase (SOD), and catalase (CAT) and the inhibition of lipid peroxides [139]. Furthermore, quercetin seems to inhibit angiogenesis by the inhibition of protein kinase C [140]. It also prevents cancer development at a physiological concentration of 5 μM by upregulating p53 and increasing the expression of Bax [141].…”

Section: 2mentioning

confidence: 99%

Plant Natural Compounds in the Treatment of Adrenocortical Tumors

Manso

Sharifi‐Rad

Zam³

et al. 2021

International Journal of Endocrinology

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Plant natural products are a plethora of diverse and complex molecules produced by the plant secondary metabolism. Among these, many can reserve beneficial or curative properties when employed to treat human diseases. Even in cancer, they can be successfully used and indeed numerous phytochemicals exert antineoplastic activity. The most common molecules derived from plants and used in the fight against cancer are polyphenols, i.e., quercetin, genistein, resveratrol, curcumin, etc. Despite valuable data especially in preclinical models on such compounds, few of them are currently used in the medical practice. Also, in adrenocortical tumors (ACT), phytochemicals are scarcely or not at all used. This work summarizes the available research on phytochemicals used against ACT and adrenocortical cancer, a very rare disease with poor prognosis and high metastatic potential, and wants to contribute to stimulate preclinical and clinical research to find new therapeutic strategies among the overabundance of biomolecules produced by the plant kingdom.

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The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells

et al. 2021

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Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells

Cited by 5 publications

References 54 publications

Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression

Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression

Plant Natural Compounds in the Treatment of Adrenocortical Tumors

The effects of the esterified Quercetin with omega3 and omega6 fatty acids on viability, nanomechanical properties, and BAX/BCL-2 gene expression in MCF-7 cells

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