Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles

Liu, Shiqi; Zhang, Jing; Fu, Rao; Feng, Hao; Chu, Yibing; Huang, Dong; Han, Lipeng; Li, Chaonan; Ma, Chao; El‐Aty, A.M. Abd

doi:10.1016/j.foodchem.2021.131498

Cited by 20 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoparticles, due to their simplicity and low cost, are a promising encapsulation technology for bioactive compounds and extensively used in biological carriers' development. They usually have various preparation methods and wall materials, but always a exhibit high loading rate, encapsulation efficiency, and storage stability, and sometimes, they even assembled themselves (Liu et al, 2022). Lee et al (2022) utilised starch nanoparticles (SNPs) to load b-carotene and found that its solubility increased in aqueous media.…”

Section: Nanoparticlesmentioning

confidence: 99%

Recent advances in the extraction, synthesis, biological activities, and stabilisation strategies for β‐carotene: a review

Zhao,

He,

Yan

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summaryβ‐carotene is a natural carotenoid pigment that widely exists in various fruits and vegetables, possessing antioxidant, anti‐inflammatory, and other biological activities. This makes it highly suitable for the development of nutritional functional foods and cosmetics. However, its poor water solubility and physical and chemical instability hinder its actual bioavailability. Therefore, adopting a rational stabilisation strategy to improve the stability and bioavailability of β‐carotene is a feasible approach. This review provides a comprehensive overview of the properties, biological activities, extraction methods, and synthesis methods of β‐carotene. It also highlights the research progress and current applications of β‐carotene‐loaded systems with the aim to offer valuable references for developing stable systems and expanding its application scope.

show abstract

Section: Nanoparticlesmentioning

confidence: 99%

Recent advances in the extraction, synthesis, biological activities, and stabilisation strategies for β‐carotene: a review

Zhao,

He,

Yan

et al. 2024

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…β-carotene (Car) has a wide range of physiological effects, but its insolubility in water leads to low bioavailability. Therefore, hydroxyl and carboxyl groups on the surface of carotene can be used to combine with organic functional groups on the surface of oleanolic acid (OA) to form hydrogen bonds ( 84 ). As shown in Figure 8 , this is a dynamic process of self-assembly of Car and OA hydrogen bonds.…”

Section: Loading and Release Mechanism Of Nano-deliverymentioning

confidence: 99%

“… Molecular dynamics (MD) simulation of Car/OA NPs. The optimal geometry of OA ( A , top), Car ( A , bottom); OA and Car dispersed in DCM before simulation (B) ; and Schematic diagram of Car/OA NPs after MD simulation for 1,000 ps (C) ; Hydrogen bonding in Car/OA NPs (D) ( 84 ). …”

Section: Loading and Release Mechanism Of Nano-deliverymentioning

confidence: 99%

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

et al. 2023

View full text Add to dashboard Cite

At present, nano-carrier materials with antibacterial activity are of great significance. Due to the widespread resistance of many pathogenic microorganisms, it has seriously threatened human health. The natural antimicrobial substances extracted from fruits and vegetables can significantly improve their stability combined with nano-carrier materials. The resistance of pathogenic microorganisms will be substantially reduced, greatly enhancing the effect of active antimicrobial substances. Nanotechnology has excellent research prospects in the food industry, antibacterial preservation, food additives, food packaging, and other fields. This paper introduces nano-carrier materials and preparation techniques for loading and encapsulating active antibacterial substances in detail by constructing a nano-release system for active antibacterial substances. The antibacterial effect can be achieved by protecting them from adverse external conditions and destroying the membrane of pathogenic microorganisms. The mechanism of the slow release of the bacteriostatic active substance is also described. The mechanism of carrier loading and release is mainly through non-covalent forces between the bacteriostatic active substance and the carrier material, such as hydrogen bonding, π-π stacking, van der Waals forces, electrostatic interactions, etc., as well as the loading and adsorption of the bacteriostatic active substance by the chemical assembly. Finally, its wide application in food and medicine is introduced. It is hoped to provide a theoretical basis and technical support for the efficient utilization and product development of bacteriostatic active substances.

show abstract

“…The NSMs were often self-assembled into the uniform spherical structures obtained by reprecipitation or standard emulsion–solvent evaporation method, which were comprised of the inward hydrophobic backbones and the outward hydrophilic hydroxyl and carboxyl groups [ 41 , 45 , 75 ]. Vesicle is also one rare and valuable kind of spherical manifestation with distinct membrane structure in self-assemblied NSMs, which can be formed in aqueous medium spontaneously.…”

Section: Directly Assembly Mechanism Of Supramolecular Natural Productsmentioning

confidence: 99%

“…The in vitro release profiles of OA–Car NPs denoted that the Car would be released preferentially in simulated intestinal fluid, which could prevent it from early degradation in simulated gastric fluid. It was suggested that the release of OA–Car NPs significantly associated with the release medium [ 75 ]. Cheng et al.…”

Section: Applications Of Supramolecular Assemblies Based On Nsmsmentioning

confidence: 99%

Supramolecular assemblies based on natural small molecules: Union would be effective

Hou

Zou

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

Improved stability and aqueous solubility of β-carotene via encapsulation in self-assembled bioactive oleanolic acid nanoparticles

Cited by 20 publications

References 37 publications

Recent advances in the extraction, synthesis, biological activities, and stabilisation strategies for β‐carotene: a review

Recent advances in the extraction, synthesis, biological activities, and stabilisation strategies for β‐carotene: a review

Construction of nano slow-release systems for antibacterial active substances and its applications: A comprehensive review

Supramolecular assemblies based on natural small molecules: Union would be effective

Contact Info

Product

Resources

About