Improved ß-Carotene and Lycopene Production by Blakeslea trispora with Ultrasonic Treatment in Submerged Fermentation

Wang, Hongbo; Xu, Rong-Gang; Yu, Long-Jiang; Luo, Jun; Zhang, Liwei; Huang, Xiaoyan; Zou, Wen-An; Zhao, Qian; Lu, Mengji

doi:10.5560/znc.2013-0122

Cited by 9 publications

(6 citation statements)

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“…Sugar metabolism was slightly enhanced at the beginning of fermentation and increased during next fermentation period. This increase may provide more lycopene production [22]. On the other hand, biomass formation increased continuously during the 6 days of fermentation and it slowed on last day.…”

Section: Discussionmentioning

confidence: 99%

Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora

Sevgili

Erkmen

2019

Foods

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The production of lycopene from different substrates by Blakeslea trispora in fermentation was investigated. Lycopene productions from 4 and 6% glucose (pH 6.5) in shake flask fermentation were 77.7 and 28.1 mg L−1. Increasing the glucose concentration to 6% resulted in a decrease in lycopene production by 36.2%. A maximum lycopene concentration of 944.8 mg L−1 was detected with 4% glucose supplemented with 1.0 % sunflower oil in fermentor studies. Lycopene productions in the presence of sunflower and corn oils in the fermentor were 12.2 and 11.1 times higher, respectively, then without oil from 4 % glucose in a shake flask. Lycopene production from orange peel was two times higher in the fermentor than in the shake flask. Zygospores of B. trispora are the morphological forms, which are responsible for the production of the lycopene. The highest level of zygospores was correlated with the highest amount of intracellular lycopene in the total biomass dry weight. The media containing only orange powder (1%) gave a 4.9 mg L−1 lycopene production in a fermentor. The biosynthesis of lycopene has been started in most cases simultaneously in the early growth phase even in trace amounts. Maximum lycopene concentration was obtained when the medium was supplied with sunflower and corn oils. There is an indirect relationship between biomass and lycopene concentration.

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Section: Discussionmentioning

confidence: 99%

Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora

Sevgili

Erkmen

2019

Foods

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“…84 An ultrasonic treatment of B. trispora resulted in the production of 173 and 82 mg/L of β-carotene and lycopene, respectively. 85 An increase in yield was observed in β-carotene from 44% to 65% and lycopene from 51% to 78% when n-hexane and n-dodecane were incorporated in the media. The addition of antibiotics, natural oils, amino acids, and vitamin A in culture media of B. trispora resulted in a significant increase in yield of β-carotene.…”

Section: Sources Of Carotenoidsmentioning

confidence: 95%

“…An ultrasonic treatment of B . trispora resulted in the production of 173 and 82 mg/L of β-carotene and lycopene, respectively . An increase in yield was observed in β-carotene from 44% to 65% and lycopene from 51% to 78% when n -hexane and n -dodecane were incorporated in the media.…”

Section: Sources Of Carotenoidsmentioning

confidence: 99%

Selected Methods of Extracting Carotenoids, Characterization, and Health Concerns: A Review

Adadi

Barakova

Krivoshapkina

2018

J. Agric. Food Chem.

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Carotenoids are the most powerful nutrients (medicine) on earth due to their potent antioxidant properties. The ability of these tetraterpenoids in obviating human chronic ailments like cancer, cardiovascular disease, osteoporosis, and diabetes has drawn public attention toward these novel compounds. Conventionally, carotenoids have been extracted from plant materials and agro-industrial byproduct using different solvents, but these procedures result in contaminating the target compound (carotenoids) with extraction solvents. Furthermore, some utilized solvents are not safe and hence are harmful to the environment. This has attracted criticism from consumers, ecologists, environmentalists, and public health workers. However, there is clear consumer preference for carotenoids from natural origin without traces of extracting solvent. Therefore, this review seeks to discuss methods for higher recovery of pure carotenoids without contamination from a solvent. Methods such as enzyme-based extraction, supercritical fluid extraction, microwave-assisted extraction, Soxhlet extraction, ultrasonic extraction, and postextraction treatment (saponification) are discussed. Merits and demerits of these methods along with health concerns during intake of carotenoids were also considered.

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“…The biosynthesis of beta-carotene from Blakeslea trispora was significantly promoted by ultrasonic treatment. After ultrasonic simulation, the beta-carotene yield increased by 40.7% in the study by Wang et al [ 32 ].…”

Section: The Extraction and Synthesis Of Beta-carotenementioning

confidence: 99%

Beta-carotene and its protective effect on gastric cancer

Chen¹,

Wu²,

Pan³

et al. 2021

WJCC

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Beta-carotene is an important natural pigment that is very beneficial to human health. It is widely found in vegetables and fruits. The three main functions are antioxidant effects, cell gap junction-related functions and immune-related functions. Because of its diverse functions, beta-carotene is believed to prevent and treat many chronic diseases. Gastric cancer is one of the most important diseases it can treat. Gastric cancer is a type of cancer with a high incidence. Its etiology varies, and the pathogenesis is complex. Gastric cancer seriously affects human health. The role of beta-carotene, a natural nutrient, in gastric cancer has been explored by many researchers, including molecular mechanisms and epidemiological studies. Molecular studies have mainly focused on oxidative stress, cell cycle, signal transduction pathways and immune-related mechanisms of beta-carotene in gastric cancer. Many epidemiological surveys and cohort studies of patients with gastric cancer have been conducted, and the results of these epidemiological studies vary due to the use of different research methods and analysis of different regions. This paper will summarize the results of these studies, mainly in terms of molecular mechanisms and epidemiological research results, which will provide a systematic basis for future studies of the treatment and prognosis of gastric cancer. This paper will help researchers identify new research directions.

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Improved ß-Carotene and Lycopene Production by Blakeslea trispora with Ultrasonic Treatment in Submerged Fermentation

Cited by 9 publications

References 0 publications

Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora

Improved Lycopene Production from Different Substrates by Mated Fermentation of Blakeslea Trispora

Selected Methods of Extracting Carotenoids, Characterization, and Health Concerns: A Review

Beta-carotene and its protective effect on gastric cancer

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