Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy

Cardoso, Fabrízio Dos Santos; Tavares, Cristiane de Souza Oliveira; Araújo, Bruno Henrique Silva; Mansur, Fernanda; Lopes-Martins, Rodrigo Álvaro Brandão; Silva, Sérgio Gomes da

doi:10.1007/s10571-021-01069-4

Cited by 19 publications

(16 citation statements)

References 62 publications

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“…Many studies have reported improvement in cognitive function in various neurodegenerative diseases after PBM [25][26][27] ; therefore, PBM irradiation may also improve behavioral and cognitive function in the SE model. In www.nature.com/scientificreports/ the present study, the behavioral test (shown in our supplementary data S1) investigated whether PBM alleviated the symptoms of depression or anxiety induced by SE.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model

Hong

Kang

Park

et al. 2022

Sci Rep

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Status epilepticus (SE) refers to a single seizure that lasts longer than typical seizures or a series of consecutive seizures. The hippocampus, which is vulnerable to the effects of SE, has a critical role in memory storage and retrieval. The trisynaptic loop in the hippocampus connects the substructures thereof, namely the dentate gyrus (DG), CA3, and CA1. In an animal model of SE, abnormal neurogenesis in the DG and aberrant neural network formation result in sequential neural degeneration in CA3 and CA1. Photobiomodulation (PBM) therapy, previously known as low-level laser (light) therapy (LLLT), is a novel therapy for the treatment of various neurological disorders including SE. However, the effects of this novel therapeutic approach on the recovery process are poorly understood. In the present study, we found that PBM transformed SE-induced abnormal neurogenesis to normal neurogenesis. We demonstrated that PBM plays a key role in normal hippocampal neurogenesis by enhancing the migration of maturing granular cells (early neuronal cells) to the GCL, and that normal neurogenesis induced by PBM prevents SE-induced hippocampal neuronal loss in CA1. Thus, PBM is a novel approach to prevent seizure-induced neuronal degeneration, for which light devices may be developed in the future.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model

Hong

Kang

Park

et al. 2022

Sci Rep

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“…Many human studies have demonstrated the potential of transcranial PBM for the augmentation of neurocognitive functions under several conditions ( 1 , 46 – 54 ). Studies using laboratory animals have also documented interesting results of brain PBM ( 45 , 55 , 56 ). For example, our research group submitted aged rats to PBM with transcranial laser for 58 consecutive days and we noted that laser treatment was able to rejuvenate the spatial mnemonic damage of the aged rats and modulate brain levels of inflammatory markers ( 56 ).…”

Section: Neurocognitive Effects Of Photobiomodulation In Humansmentioning

confidence: 94%

“…Studies using laboratory animals have also documented interesting results of brain PBM ( 45 , 55 , 56 ). For example, our research group submitted aged rats to PBM with transcranial laser for 58 consecutive days and we noted that laser treatment was able to rejuvenate the spatial mnemonic damage of the aged rats and modulate brain levels of inflammatory markers ( 56 ). In addition, this same laser treatment protocol increased the brain metabolic pathways of young rats and restored the brain metabolic pathways of aged rats to the levels of younger rats ( 45 ).…”

Section: Neurocognitive Effects Of Photobiomodulation In Humansmentioning

confidence: 94%

Mitochondrial Photobiomodulation as a Neurotherapeutic Strategy for Epilepsy

2022

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“…Brain aging is characterized by microglia reactivity and an imbalance between pro-and anti-inflammatory cytokines (Godbout and Johnson, 2009;Jurgens and Johnson, 2012). However, a couple of recent studies involving our group have shown that PBM can improve the inflammatory response in the aging brain (Salehpour et al, 2019b;Cardoso et al, 2021aCardoso et al, , 2022Hosseini et al, 2022). For example, a protocol with 58 consecutive days of 810 nm laser PBM therapy was able to change the inflammatory profile of the aging brain in rats.…”

Section: Agingmentioning

confidence: 99%

Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

et al. 2022

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BackgroundNeuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in experimental brain research. We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy.MethodsWe conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: photobiomodulation, low-level laser therapy, brain, neuroinflammation, inflammation, cytokine, and microglia. Data search was limited from 2009 to June 2022. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The initial systematic search identified 140 articles. Among them, 54 articles were removed for duplication and 59 articles by screening. Therefore, 27 studies met the inclusion criteria.ResultsThe studies showed that PBM has anti-inflammatory properties in several conditions, such as traumatic brain injury, edema formation and hyperalgesia, ischemia, neurodegenerative conditions, aging, epilepsy, depression, and spinal cord injury.ConclusionTaken together, these results indicate that transcranial PBM therapy is a promising strategy to treat brain pathological conditions induced by neuroinflammation.

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Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy

Cited by 19 publications

References 62 publications

Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model

Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model

Mitochondrial Photobiomodulation as a Neurotherapeutic Strategy for Epilepsy

Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

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