Ultrasound is noninvasive, safe, and versatile. It seems an ideal imaging modality in the pregnant patient, in whom ionizing radiation must be kept to a minimum, yet accurate imaging is important in directing treatment. The objective of our study was to investigate the value of ultrasound as a first-line imaging modality in pregnant women with abdominal pain.We prospectively studied 41 consecutive pregnant patients with abdominal pain over a 1-year period. The setting was a busy private practice in a large teaching hospital with both a primary and tertiary care referral base.Diagnoses were categorized into urologic, biliary, bowel, and obstetric/gynecologic pathology. There were 23 positive diagnoses of the 41 patients in the series, encompassing 13 cases of urinary pathology (calculi, pyelonephritis, and overdistention syndrome), 2 cases of bowel pathology (appendicitis and Crohn's disease), 6 cases of biliary disease (gallstones and a case of choledocholithiasis), and 2 cases of obstetric/gynecologic pathology (threatened abortion and corpus luteum cyst). Ultrasound correctly diagnosed 18 of these 23 cases. The remaining 5 false-negatives were 3 cases of urinary calculi, 1 case of appendicitis, and 1 case ofcholedocholithiasis. There were 18 true-negatives and no false-positives. The sensitivity of ultrasound in our series was 78%, specificity was 100%, and overall accuracy was 88%.Although there are limited numbers of specific diagnoses, we think that our patient population as a whole represents some of the more commonly evaluated complications in pregnancy. We conclude that sonography is a valuable first-line imaging modality in diagnosis of the pregnant patient with pain.T he pregnant patient with abdominal pain poses special limitations to diagnostic imaging. Ultrasonography, which has no known adverse effects on the fetus or mother, seems an ideal imaging modality in pregnant patients. The noninvasive nature of ultrasound allows the radiologist to combine clinical and imaging skills. This paper reviews the ultrasound findings in some common conditions which present with abdominal pain in pregnancy. As a basis for this review, we report our prospective experience with 41 pregnant patients presenting with abdominal pain.Over a 12-month period, 41 consecutive pregnant patients, age 15-39 years old, were referred for ultrasound with pain as the primary indication. At the time of presentation, 8 patients were in the first trimester, 16 were in the second, and 17 were in the third trimester of pregnancy.In our institution, the ultrasound examination is focused on the clinical question, i.e., "rule out ureteral calculus," but a brief survey of the remainder of the abdomen and pelvis is also performed. In cases specifically referred for renal pathology, Doppler sonography, including color imaging, is used as appropriate. Ureteral jets are sought in patients with suspected obstruction. Pathologic hydronephrosis is considered when the transverse diameter of the renal pelvis exceeds the norm for gestational age (1).T...