Improved Signs, Symptoms, and Quality of Life Associated With Dry Eye Syndrome: Hydroxypropyl Cellulose Ophthalmic Insert Patient Registry

Koffler, Bruce H.; McDonald, Marguerite B.; Nelinson, Donald S.

doi:10.1097/icl.0b013e3181db352f

Cited by 28 publications

(21 citation statements)

References 15 publications

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“…23 Schiffman et al 23 recommended the use of OSDI as an endpoint in clinical trials. Several recent studies of dry eye syndrome 30-32 and 1 study of ocular GVHD 33 used changes in OSDI as an endpoint. Our results showed that changes in OSDI correlated with clinician- and patient-reported symptom changes in ocular GVHD.…”

Section: Discussionmentioning

confidence: 99%

Validation of Measurement Scales in Ocular Graft-versus-Host Disease

et al. 2012

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Purpose To validate measurement scales for rating ocular chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation. Candidate scales were recommended for use in clinical trials by the National Institutes of Health (NIH) Chronic GVHD Consensus Conference or have been previously validated in dry eye syndromes. Design Prospective follow-up study. Participants Between August 2007 and June 2010, the study enrolled 387 patients with chronic GVHD in a multicenter, prospective, observational cohort. Methods Using anchor-based methods, we compared clinician or patient-reported changes in eye symptoms (8-point scale) with calculated changes in 5 candidate scales: The NIH eye score, patient-reported global rating of eye symptoms, Lee eye subscale, Ocular Surface Disease Index, and Schirmer test. Change was examined for 333 follow-up visits where both clinician and patient reported eye involvement at the previous visit. Linear mixed models were used to account for within-patient correlation. Main Outcome Measures An 8-point scale of clinician or patient-reported symptom change was used as an anchor to measure symptom changes at the follow-up visits. Results In serial evaluations, agreement regarding improvement, stability, or worsening between the clinician and patient was fair (weighted kappa = 0.34). Despite only fair agreement between evaluators, all scales except the Schirmer test correlated with both clinician-reported and patient-reported changes in ocular GVHD activity. Among all scales, changes in the NIH eye scores showed the greatest sensitivity to symptom change reported by clinicians or patients. Conclusions Our results support the use of the NIH eye score as a sensitive measure of eye symptom changes in clinical trials assessing treatment of chronic GVHD.

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Section: Discussionmentioning

confidence: 99%

Validation of Measurement Scales in Ocular Graft-versus-Host Disease

et al. 2012

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“…Because the formulation is preservative free, it may help patients who are not able or willing to use artificial tears on a frequent basis [96,97]. Published clinical evidence of efficacy (level II) has reported a significant improvement in tear deficiency symptoms and OSDI scores with once-daily use of hydroxypropyl cellulose ophthalmic inserts [98,99]. Transient blurred vision was the most common adverse event reported that was associated with use of the hydroxypropyl cellulose ophthalmic inserts [97,98].…”

Section: Treatment Options For Dysfunctional Tear Syndromementioning

confidence: 99%

Dysfunctional tear syndrome

Milner

Beckman

Luchs

et al. 2017

Current Opinion in Ophthalmology

161

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Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013). Since the publication of the existing guidelines, new diagnostic techniques and treatment options that provide an opportunity for better management of patients have become available. Clinicians are now able to access a wealth of information that can help them obtain a differential diagnosis and treatment approach for patients presenting with DTS. This review provides a practical and directed approach to the diagnosis and treatment of patients with DTS, emphasizing treatment that is tailored to the specific disease subtype as well as the severity of the condition.

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“…Dry eye is a multifactorial ocular surface disorder which is usually caused by chronic inflammation and characterized by tear film instability and increased osmolarity [1, 2]. There are various symptoms in dry eye patients, such as ocular discomfort, fluctuating visual disturbances, and potential damage [3].…”

Section: Introductionmentioning

confidence: 99%

Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Song

Zhang

et al. 2017

Journal of Ophthalmology

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Purpose. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye. Methods. In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score. Results. Our correlation analyses showed that rounding of lid margins, notching of lid margins, vascularity of lid margins, hyperkeratinization, plugging of orifices, main duct dropout, and conjunctival congestion all had a positive correlation with OSDI score, while main duct number (central 1 cm) and BUT had a negative one. Further analysis suggested that these correlations varied in different age groups. Multiple linear regression analysis indicated that main duct number (central 1 cm), rounding of lid margins, and hyperkeratinization significantly affected OSDI score. Conclusions. Close attention should be paid to the morphology and structure of the eyelid margin and the function of meibomian gland in the diagnosis, treatment, and follow-up of dry eye diseases.

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Improved Signs, Symptoms, and Quality of Life Associated With Dry Eye Syndrome: Hydroxypropyl Cellulose Ophthalmic Insert Patient Registry

Abstract: Hydroxypropyl cellulose ophthalmic inserts significantly improved signs and symptoms of moderate-to-severe DES, as well as ADL and QoL. Benefits were additive to those seen with patients' existing care.

Cited by 28 publications

References 15 publications

Validation of Measurement Scales in Ocular Graft-versus-Host Disease

Validation of Measurement Scales in Ocular Graft-versus-Host Disease

Dysfunctional tear syndrome

Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

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