Improved segmentation of the intracranial and ventricular volumes in populations with cerebrovascular lesions and atrophy using 3D CNNs

Abstract

Successful segmentation of the total intracranial vault (ICV) and ventricles is of critical importance when studying neurodegeneration through neuroimaging. We present iCVMapper and VentMapper, robust algorithms that use a convolutional neural network (CNN) to segment the ICV and ventricles from both single contrast and multi-contrast MRI data. Our models were trained on a large dataset from two multi-site studies (N=528 subjects for ICV, N=501 for ventricular segmentation) consisting of older adults with varying degrees of cerebrovascular lesions and atrophy, posing significant challenges for most segmentation approaches. The models were tested on 132 participants, including subjects with high white matter hyperintensity burden from a third multi-site study not used in the training dataset. We assessed our algorithms relative to four state-of-the-art ICV extraction methods (MONSTR, BET, Deep Extraction, Freesurfer), as well as an open source ventricular segmentation tool (Freesurfer). Our multicontrast models outperformed other methods across all evaluation metrics, with an average Dice coefficient of 0.98 and 0.94 for ICV and ventricular segmentation respectively. Both models were also the most time efficient, segmenting the structures in seconds; orders of magnitude faster than some of the other available methods. Our networks showed further improvement in accuracy with the use of a conditional random field (CRF) as a post-processing step. We further validated both segmentation models, highlighting their robustness to images with lower resolution and signal-to-noise ratio. The pipeline and models are available at: https://ventmapp3r.readthedocs.io and https://icvmapp3r.readthedocs.io to enable further investigation of the roles of ICV and ventricles in relation to normal aging and neurodegeneration in large multi-site studies.

Cortical thickness estimation in individuals with cerebral small vessel disease, focal atrophy, and chronic stroke lesions

“…The ability to decrease the failure rate was the key strength of this work. Although our correction procedures were derived from ONDRI's imaging pipeline, similar correction procedures that can account for vascular lesions and brain atrophy could be applied in other studies using FS (or any number of cortical thickness estimation tools) to study challenging clinical popu-lations (50,(76)(77)(78). Hence, the decision to validate and apply this method to individuals with CVD presenting with a range of various combined pathologies including focal and global atrophy, large and small cortico-subcortical chronic stroke lesions, diffuse and focal WMH, lacunar infarcts, cortical microinfarcts, and enlarged PVS (48,79).…”

Brain atrophy trajectories predict differential functional performance in Alzheimer's disease: Moderations with apolipoprotein E and sex

“…Higher BPF corresponds to lower atrophy. Brain volumetrics were estimated from structural MRI using a previously published and validated segmentation algorithm 32–35 …”

Cortical Thickness Estimation in Individuals With Cerebral Small Vessel Disease, Focal Atrophy, and Chronic Stroke Lesions

“…The ability to decrease the failure rate was the key strength of this work. Although our correction procedures were derived from ONDRI’s imaging pipeline, similar correction procedures that can account for vascular lesions and brain atrophy could be applied in other studies using FS (or any number of cortical thickness estimation tools) ( Magon et al, 2014 ) to study challenging clinical populations ( Dalca et al, 2014 ; Dadar et al, 2017 ; Subbanna et al, 2019 ; Ntiri et al, 2020 ). Hence, the decision to validate and apply this method to individuals with CVD presenting with a range of various combined pathologies including focal and global atrophy, large and small cortico-subcortical chronic stroke lesions, diffuse and focal WMH, lacunar infarcts, cortical microinfarcts, and enlarged PVS ( Gorelick et al, 2011 ; Wardlaw et al, 2013 ).…”