/ Spills of toxic materials into bodies Of water receiving industrial waste discharges can.be prevented only if frequent or.continuous assessments of effluent quality can be made. Currently available methods can automatically measure individual physical or chemical waste component s but cannot assess toxicity caused by the interaction of components or the presence of an unsuspected matedai. Aquatic organisms, in contrast, respond to their total environment and in this way integrate the effects of all 9 the va(4ous chemical and physical waste parameters.This study evaluates the possibility of using the continuously and automatically recorded responses of fish to monitor the toxicity of industrial waste effluents. A review of previously developed toxicity monitoring systems iS followed by a field evaluation of a method tha~t uses the computer-monitored ventilatory patterns of 12 bluegills (Lepomis macrochirusRafinesque) to monitor the toxicity of an industrial waste effluent as it flows into a river. No known tox!c.spills occurred in the effluent during the operation of this system, but acetone added to the effluent waste caused responses from the fish at concentrations which peaked near the 96-hr LC~o level. Some responses were also noted when no known toxicant was present; these were/elated to environmental disturbances and system design problems. Recommendations are made for the design of future biologic monitoring units.