“…Indeed, several studies report that WMLs are associated with a history of stroke [6,19,21,23,25,33], the presence of lacunar infarcts [6,7,9,34], heart disease [18,[23][24][25]35], atrial fibrillation [33], peripheral vascular disease [6,18,23], diabetes mellitus [6], risk factors for arteriosclerosis [6], smoking [23] and renal arteriolar sclerosis [3]. However, there are also studies reporting no association with hypertension [33,[35][36][37][38] or blood pressure levels [39,40], and some report associations with low blood pressure [33]. Furthermore, even in studies reporting an association with hypertension, a large proportion of patients do not have hypertension [10,20,22].…”