“…Intravenous or oral premedication with clonidine, an α-2 adrenoceptor agonist, effectively reduces bleeding (5) , shortens surgical times (6) , and provides better visualisation of the surgical field and a more favourable haemodynamic profile (7) during ESS. Furthermore, peripheral or local administration of clonidine has also proven helpful in regional anaesthesia, neuraxial blockade, and intra-articular analgesia (8) .…”