Improved prefrontal activity in AD/HD children treated with atomoxetine: A NIRS study

Araki, Akiko; Ikegami, Masanaga; Okayama, Akie; Matsumoto, Naoya; Takahashi, Satoru; Azuma, Hiroshi; Takahashi, Masaharu

doi:10.1016/j.braindev.2014.03.011

Cited by 34 publications

(24 citation statements)

References 55 publications

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“…The CPT has been used to evaluate the effects of a pharmacological treatment on prefrontal activity in children with ADHD (Araki, et al, 2014). In an age-matched control group, children had increased oxygenated hemoglobin (oxy-Hb) concentration in the bilateral dorsolateral PFC (dlPFC).…”

Section: Measurements Of Rri In Humansmentioning

confidence: 99%

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Hamilton

Littlefield

Anastasio³

et al. 2015

Personality Disorders: Theory, Research, and Treatment

135

110

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Impulsivity is a multi-faceted construct that is a core feature of multiple psychiatric conditions and personality disorders. However, progress in understanding and treating impulsivity in the context of these conditions is limited by a lack of precision and consistency in its definition and assessment. Rapid-response-impulsivity (RRI) represents a tendency toward immediate action that occurs with diminished forethought and is out of context with the present demands of the environment. Experts from the International Society for Research on Impulsivity (InSRI) met to discuss and evaluate RRI-measures in terms of reliability, sensitivity, and validity with the goal of helping researchers and clinicians make informed decisions about the use and interpretation of findings from RRI-measures. Their recommendations are described in this manuscript. Commonly-used clinical and preclinical RRI-tasks are described, and considerations are provided to guide task selection. Tasks measuring two conceptually and neurobiologically distinct types of RRI, “refraining from action initiation” (RAI) and “stopping an ongoing action” (SOA) are described. RAI and SOA-tasks capture distinct aspects of RRI that may relate to distinct clinical outcomes. The InSRI group recommends that: 1) selection of RRI-measures should be informed by careful consideration of the strengths, limitations, and practical considerations of the available measures; 2) researchers use both RAI and SOA tasks in RRI studies to allow for direct comparison of RRI types and examination of their associations with clinically relevant measures; and, 3) similar considerations should be made for human and non-human studies in an effort to harmonize and integrate pre-clinical and clinical research.

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Section: Measurements Of Rri In Humansmentioning

confidence: 99%

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Hamilton

Littlefield

Anastasio³

et al. 2015

Personality Disorders: Theory, Research, and Treatment

135

110

View full text Add to dashboard Cite

show abstract

“…They found that ATX induced an intensified prefrontal hemodynamic response [31]. In another NIRS study, Araki et al found that the oxy-Hb concentration in the right dorsolateral PFC in the post-ATX condition was significantly increased compared to the pre-ATX condition during a continuous performance task [32]. Despite several NIRS studies with ADHD, only a few studies have examined the therapeutic effects of medication.…”

Section: Introductionmentioning

confidence: 99%

Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy

Nakanishi

Ota

Iida

et al. 2017

Child Adolesc Psychiatry Ment Health

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BackgroundThe stimulant methylphenidate (MPH) and the nonstimulant atomoxetine (ATX) are the most commonly-prescribed pharmacological treatments for attention deficit/hyperactivity disorder (ADHD). However, the drug-specific mechanism of action on brain function in ADHD patients is not well known. This study examined differences in prefrontal hemodynamic activity between MPH and ATX in children with ADHD as measured by near-infrared spectroscopy (NIRS) using the Stroop color-word task.MethodsThirty children with ADHD participated in the present study. We used 24-channel NIRS (ETG-4000) to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received MPH (n = 16) or ATX (n = 14) for 12 weeks. Measurements were conducted every 0.1 s during the Stroop color-word task. We used the ADHD RS-IV-J (Home Version) to evaluate ADHD symptoms.ResultsTreatment with either MPH or ATX significantly reduced ADHD symptoms, as measured by the ADHD RS-IV-J, and improved performance on the Stroop color-word task in terms of number of correct words. We found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the ATX condition compared with the values seen at baseline (pre-ATX). In contrast, we found no oxyhemoglobin changes between pre- and post-treatment with MPH.ConclusionsThe present study suggests that MPH and ATX have differential effects on prefrontal hemodynamic activity in children with ADHD.

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“…Changes in brain activation levels using fNIRS have been found to differentiate known clinical groups from typically developing children (Ishii-Takahashi et al, 2014, Wiley et al, 2014) and to be related to parent-reported measures of behavioral functioning (Perlman et al, 2014). Changes in activation obtained from fNIRS have already been used to assess the impact of pharmacological interventions for children with Attention Deficit-Hyperactivity Disorder (ADHD) (Oner et al, 2011, Schecklmann et al, 2011, Monden et al, 2012, Matsuura et al, 2014, Araki et al, 2015) but have not yet been applied to understanding individual differences in children with FASDs.…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study

Kable

Coles

2017

Clinical Neurophysiology

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Objective Disruption in the neural activation of the prefrontal cortex (PFC) in modulating arousal was explored in children with heavy prenatal alcohol exposure (PAE), who have known neurobehavioral impairment. Methods During a task that elicits frustration, functional near-infrared spectroscopy (fNIRS) was used to measure PFC activation, specifically levels of oxygenated (HBO) and deoxygenated (HBR) hemoglobin, in children with PAE (n=18) relative to typically developing Controls (n=12) and a Clinical Contrast group with other neurodevelopmental or behavioral problems (n=14). Results Children with PAE had less activation during conditions with positive emotional arousal, as indicated by lower levels of HBO in the medial areas of the PFC and higher levels of HBR in all areas of the PFC sampled relative to both other groups. Children in the Control group demonstrated greater differentiation of PFC activity than did children with PAE. Children in the Clinical Contrast group demonstrated the greatest differences in PFC activity between valences of task conditions. Conclusions: Specific patterns of PFC activation differentiated children with PAE from typically developing children and children with other clinical problems. Significance FNIRS assessments of PFC activity provide new insights regarding the mechanisms of commonly seen neurobehavioral dysfunction in children with PAE.

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Improved prefrontal activity in AD/HD children treated with atomoxetine: A NIRS study

Abstract: These results suggest that long-term treatment with ATX improved prefrontal hemodynamic activity in AD/HD children, and NIRS may be useful for assessment of the prefrontal hemodynamic response to ATX treatment.

Cited by 34 publications

References 55 publications

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.

Differential therapeutic effects of atomoxetine and methylphenidate in childhood attention deficit/hyperactivity disorder as measured by near-infrared spectroscopy

Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study

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