Clay–sand–clay deposits are commonly encountered in the offshore field. For spudcan installation in this soil stratigraphy, the potential for punch-through exists, with the peak penetration resistance formed within the interbedded sand layer. Therefore, a careful assessment of the penetration resistance profile has to be performed. Based on the recently proposed failure-stress-dependent model, this paper presents a modified predictive model for estimating the peak resistance. The modified model incorporates the bearing capacity depth factor and the protruded soil plug in the bottom clay layer into the formulation. It is proven that the modified predictive model provides improved deterministic estimations for the peak resistances measured in centrifuge tests. Based on the modified predictive model, a parameter optimization technique is utilized to optimize the prediction of peak resistance using penetration resistances observed beforehand. A detailed application procedure is proposed and applied to the centrifuge tests accumulated from existing publications, with further improvement on the predictions demonstrated. The proposed parameter optimization procedure combined with the modified predictive model provides an approach to perform real-time optimization for assessing spudcan peak resistance in clay–sand–clay deposits.