We propose an effective method of extracting targets from a region-of-interest (ROI) in infrared images by using a 2-D histogram, considering intensity values and distance values from a center of the ROI. Existing approaches for extracting targets have utilized only intensity values of pixels or an analysis of a 1-D histogram of intensity values. Because the 1-D histogram has mixed bins containing false-negative bins from the target region as well as false-positive bins from the background region, it is difficult to extract target regions effectively due to the mixed bins. In order to solve the problem of the mixed bins, we propose a novel 2-D histogrambased approach for extracting targets. Experimental results have shown that the proposed method achieves better performance of extracting targets than existing methods under various environments, such as target regions with irregular intensities, dim targets, and cluttered backgrounds. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).