Improved palliation of cerebral metastases in epithelial ovarian cancer using a combined modality approach including chemotherapy, radiation therapy, and surgery

Rodriguez, Giovanna; Soper, JT; Berchuck, A.; Oleson, James R.; Clarke‐Pearson, Daniel L.

doi:10.1016/0090-8258(92)90611-l

Cited by 19 publications

(53 citation statements)

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“…11) All of 15 ovarian cancer patients with brain metastases who received radiotherapy showed improvement in neurological symptoms. 34) The present study, which included ovarian cancer, uterine cervical cancer, and uterine corpus cancer, observed improvements of neurological function in 10 of 18 Brain Metastases From Gynecological Cancers patients after treatment.…”

Section: Discussionmentioning

confidence: 96%

Treatment and Prognosis of Brain Metastases From Gynecological Cancers

Ogawa

Yoshii

Aoki

et al. 2008

Neurol. Med. Chir.(Tokyo)

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Brain metastases from gynecological cancers were retrospectively investigated in 18 patients who were treated between 1985 and 2006. Six patients received surgical resection followed by radiotherapy, and 12 patients received only radiotherapy. The median survival for all patients was 4.1 months (range 0.7-48.2 months), and the actuarial survival rates were 11% at both 12 months and 24 months. Univariate analysis showed that treatment modality, extracranial disease status, total radiation dose, number of brain metastases, and Karnofsky performance status (KPS) all had statistically significant impacts on survival. Two patients survived for more than 2 years, and both had single brain metastasis, inactive extracranial disease, 90-100% KPS, and were treated with surgical resection followed by radiotherapy. Improvements in neurological symptoms were observed in 10 of the 12 patients treated with palliative radiotherapy, with median duration of 3.1 months (range 1.5-4.5 months). The prognoses for patients with brain metastases from gynecological cancers were generally poor, although selected patients may survive longer with intensive brain tumor treatment. Palliative radiotherapy was effective in improving the quality of the remaining life for patients with unfavorable prognoses.

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Section: Discussionmentioning

confidence: 96%

Treatment and Prognosis of Brain Metastases From Gynecological Cancers

Ogawa

Yoshii

Aoki

et al. 2008

Neurol. Med. Chir.(Tokyo)

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“…Several meta-analyses of up to 194 patients have been conducted in an effort to formulate therapeutic guidelines [8,[12][13][14]. A review of the English literature dealing with the relatively large series of patients with brain metastases from EOC is presented in order to assist the management of this interesting yet rare clinical entity.…”

Section: Introductionmentioning

confidence: 99%

Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

2006

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Key Words. Brain metastases • Surgery • Stereotactic radiosurgery • Whole-brain radiotherapy • Chemotherapy Learning ObjectivesAfter completing this course, the reader will be able to:1. Select the appropriate treatment strategies for ovarian cancer patients with solitary brain metastases and extracranial disease.2. Describe the most important prognostic factors for ovarian cancer patients with brain metastases.3. List the diagnostic steps needed to establish the diagnosis of brain metastases in ovarian cancer patients.

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“…This therapeutic approach has some advantages, such as the simple way of administration that in most cases can be done on outpatient basis or with few days hospitalization, its action on cancer cells that can be eventually presents in the whole body and the fact that it does not damage the brain tissues causing dementia or brain atrophy (Pectasides, 2006) On the other side, the poor clinical conditions of some patients, the aggressivity of these treatments and the fact that many chemotherapy agents seem not to pass the blood brain barrier can contraindicate this procedure. Many authors demonstrated that chemotherapy actually results in a remission of the disease and in an increased survival (Cooper, 1994;Cormio, 1995, Rodriguez, 1992Watanabe, 2005) An analysis conducted on 15 studies by Mc Meekin et al showed that chemotherapy has an important role because is the only therapeutic approach that, as the surgical treatment, really improves survival. (Mc Meekin, 2001).…”

Section: Chemotherapymentioning

confidence: 99%

“…(Mc Meekin, 2001). The best choice for their ability to pass the blood brain barrier seem to be cisplatin and other platin-based drugs, etoposide, gemcitabine, docetaxel (Cormio, 1995;Melichar, 2004;Rodriguez, 1992;Vlasved, 1990;Salvati, 1994;Watanabe, 2005) …”

Section: Chemotherapymentioning

confidence: 99%