Improved Outcomes with Advancements in High Intensity Focused Ultrasound Devices for the Treatment of Localized Prostate Cancer

Uchida, Τοyoaki; Tomonaga, Tetsuro; Kim, Hakushi; Nakano, Masaaki; Shoji, Shuichi; Nagata, Yasutoshi; Terachi, Toshiro

doi:10.1016/j.juro.2014.07.096

Cited by 74 publications

(57 citation statements)

References 21 publications

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“…Uchida and colleagues [15] have shown that successive improvements in technology of the HIFU device results in improvements in disease control in a total of 918 patients over a 13-yr period. The 10-yr overall and cancer-specific survival was 89.6% and 97.4%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort

et al. 2016

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“…The FDA safety limit for diagnostic ultrasound use is to be within an MI of 1.9 (FDA, 2008). However, the FDA has approved of HIFU for the treatment of uterine fibroids (Tempany et al, 2003), pain palliation of metastatic bone cancer (Catane et al, 2007), and most recently prostate cancer (Crouzet et al, 2014; Uchida et al, 2014). Clinical trials for some neurological diseases, such as essential tremor disorder, are currently underway (Lipsman et al, 2013).…”

Section: Safety Of Focused Ultrasound and Microbubble Mediated Blomentioning

confidence: 99%

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

2017

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The range of therapeutic treatment options for central nervous system (CNS) diseases is greatly limited by the blood-brain barrier (BBB). While a variety of strategies to circumvent the blood-brain barrier for drug delivery have been investigated, little clinical success has been achieved. Focused ultrasound (FUS) is a unique approach whereby the transcranial application of acoustic energy to targeted brain areas causes a noninvasive, safe, transient, and targeted opening of the BBB, providing an avenue for the delivery of therapeutic agents from the systemic circulation into the brain. There is a great need for viable treatment strategies for CNS diseases, and we believe that the preclinical success of this technique should encourage a rapid movement towards clinical testing. In this review, we address the versatile applications of FUS-mediated BBB opening, the safety profile of the technique, and the physical and biological mechanisms that drive this process.

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“…The risk after salvage cryotherapy is slightly higher at 10–11.7% (16,25). The incidence of urethral stenosis after HIFU is around 10% (1.8–40%) in the primary setting and 15-20% in salvage setting, mostly seen in the bladder neck and prostatic urethra (16,22,26,27). …”

Section: Introductionmentioning

confidence: 99%

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

Nicholson

Al-Hakeem

Maldonado

et al. 2017

Transl. Androl. Urol.

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The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment. Recalcitrant strictures are most commonly managed with urethroplasty, while recalcitrant stenosis is relatively rare yet almost always associated with bothersome urinary incontinence, requiring bladder neck reconstruction and subsequent artificial urinary sphincter (AUS) implantation, or urinary diversion for the devastated outlet.

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Improved Outcomes with Advancements in High Intensity Focused Ultrasound Devices for the Treatment of Localized Prostate Cancer

Abstract: Long-term followup of patients with high intensity focused ultrasound demonstrated improved clinical outcomes due to technical, imaging and technological advancements.

Cited by 74 publications

References 21 publications

Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort

Medium-term Outcomes after Whole-gland High-intensity Focused Ultrasound for the Treatment of Nonmetastatic Prostate Cancer from a Multicentre Registry Cohort

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

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