Improved outcomes of feeding low birth weight infants with predominantly raw human milk versus donor banked milk and formula

Dritsakou, Kalliopi; Liosis, Georgios; Valsami, Georgia; Polychronopoulos, Evangelos; Skouroliakou, Maria

doi:10.3109/14767058.2015.1038232

Cited by 37 publications

(86 citation statements)

References 47 publications

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“…Though, there is an ongoing number of studies that support the opposite view. These studies have shown that, when preterm raw or donor banked milk is either targeted fortified or under adjustable fortification (individualized fortification), is capable of inducing improved short-term outcomes on neonatal somatometric characteristics, as compared with feeding mainly with a preterm formula [14,16,17] . In our recently conducted study (Dritsakou K., Liosis G. et al, 2015), infants fed mainly with a preterm formula presented smaller somatometric characteristics, at hospital discharge, when compared to those infants that were fed with targeted fortified human milk.…”

Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

“…In our recently conducted study (Dritsakou K., Liosis G. et al, 2015), infants fed mainly with a preterm formula presented smaller somatometric characteristics, at hospital discharge, when compared to those infants that were fed with targeted fortified human milk. It is remarkable that preterm infants fed with the absolute human milk diet, that is targeted fortified, regain earlier their birth weight and present fewer episodes of feeding intolerance [16] . It is obvious that by including the, necessary for a proper growth, hormones, the macronutrients and micronutrients, the growth factors and all the other elements that are necessary for development, human breast milk is thought as the most complete food for the earliest stages of life.…”

Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

“…Due to the HMBANA's suggestions on human milk banking, the Italian Association of Human Milk Banks' guidelines as well as the latest guidelines established by Ketan et al (2014), a mother is not eligible to become a donor, when consumes illegal drugs, nicotine, tobacco or alcohol products (>2 ounces/ day) and caffeinated drinks (>3 drinks/ day). As Ketan et al, has stated, a breastfeeding mother is also not eligible for human milk donation, when has received organ or tissue transplant, and any blood or blood product transfusion during the last twelve months, is taking radioactive or is being exposed to a chemical environmental source, or finally has a mastitis or fungal infection, either suffers from an active herpes (HSV) or varicella zoster infection [15][16][17][18][19] . Due to our protocol, the first priority line for the donor banked milk, in our DHMB, is those infants thought as highest-risk.…”

Section: 'Elena Venizelou' Human Milk Bank's Operationmentioning

confidence: 99%

“…This strong movement has resulted in a significant increase in the breastfeeding indicators in BFHs. The increased awareness on the benefits of breastfeeding in Greece has also encouraged mothers to donate the excess of their milk to our DHMB [11][12][13][14][15][16][17][18][19][20] .…”

Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

“…Pasteurization is carried out by the Holder's method (by heat treating the milk to 62.5ºC for 30 minutes). On the other hand, the raw maternal milk is kept in the refrigerator at 0ºC to 4ºC, after being expressed, and is fed to the infant in 24 hours, after the expression, without being frozen before but only refrigerated [14][15][16] .…”

Section: 'Elena Venizelou' Human Milk Bank's Operationmentioning

confidence: 99%

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Human Milk Banking: a bridge between the preterm mother and infant; the experience from a Greek Public Perinatal Center

Dritsakou

Liosis

Valsami

et al. 2015

J Adv Nutr Hum Metab

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Globally increasing scientific knowledge has acclaimed the treating of preterm infants with mother's own raw milk as well as the practice of donor human milk feeding, combined with the early initiation of breastfeeding, as a basic nutritional policy for preterm infants in Greece. Nowadays, donor human milk banking is being promoted and underpinned as the most basic element of the Greek national breastfeeding policy for preterm infants in Neonatal Intensive Care Units (NICU). Donor Human Milk Banks, besides gathering, screening, and pasteurizing donor's human milk consist a bridge between the preterm mother and infant, especially during the first days of lactation, that preterm mother's milk cannot completely fulfill her infants' needs. Human milk banking represents an advantageous tool for breastfeeding promotion. As found in recently conducted studies, preterm neonates treated only with an absolute human milk diet, including both raw maternal and donor banked milk, even from the first minutes of life, are able to initiate breastfeeding earlier compared to those infants, who are fed mainly with a preterm formula, that achieve later on time to initiate bottle-feeding. The policy of early aggressive nutrition even from the first hour of life with the minimal enteric feeding, is now practiced, by most neonatologists, in our country too, while early nutrition is also thought to be safe in terms of lifelong biological effects. For all the infants, both terms and preterms, human milk imposes a positive immune protection and enhances the emotional relationship between mother-newborn. Nonetheless, the nutritional value of preterm mother's milk is not completely defined as various analogies of macronutrients (protein, fat and carbohydrates), as well as energy have been analyzed in several studies. Reinforced bovine human milk fortifiers supplement with extra macronutrients and energy the raw and donor banked human milk, while the practice of performing targeted fortification, results in short-term improvements at hospital discharge, in neonatal anthropometric characteristics, feeding tolerance and length of stay in NICU.Keywords: baby friendly hospital; donor human milk bank; breastfeeding; preterm infants To cite this article: Kalliopi Dritsakou, et al. Human milk banking: a bridge between the preterm mother and infant; the experience from a greek public perinatal center. J Adv Nutr Hum Metab 2015; 2: e978.

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Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

Section: 'Elena Venizelou' Human Milk Bank's Operationmentioning

confidence: 99%

Section: Human Milk Banking Establishment and Exclusive Breastfeedingmentioning

confidence: 99%

Section: 'Elena Venizelou' Human Milk Bank's Operationmentioning

confidence: 99%

See 3 more Smart Citations

Human Milk Banking: a bridge between the preterm mother and infant; the experience from a Greek Public Perinatal Center

Dritsakou

Liosis

Valsami

et al. 2015

J Adv Nutr Hum Metab

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Comparative effectiveness of liquid human milk fortifiers: A systematic review and meta‐analysis

et al. 2021

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Objective To determine the effectiveness of liquid human milk fortifiers (HMFs) derived from exclusive HM or hydrolyzed protein on growth, necrotizing enterocolitis (NEC), or late‐onset sepsis in North American very low‐birth‐weight (VLBW) infants compared with powder HMFs (control). Methods Prospective trials published between 2009 and 2020 were systematically reviewed, and meta‐analysis was conducted by using a random‐effects model. Results Five studies were identified for up to 591 participants across 39 centers. Study treatments included whey or casein hydrolysate HMF and exclusive HM HMF. Infants fed whey or casein hydrolysate HMF had growth differences compared with the control. No differences were found across treatments in regard to NEC or sepsis. Conclusion Very low‐quality evidence suggests greater linear growth in VLBW infants fed whey hydrolysate liquid HMF, as well as greater weight gain in those fed casein hydrolysate HMF, compared with the control. Additional prospective, multicenter randomized controlled trials are needed to confirm these estimates because of sparsity of evidence. There is insufficient evidence to support HMF decisions regarding NEC or late‐onset sepsis prophylaxis.

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Milk microbiome transplantation: recolonizing donor milk with mother's own milk microbiota

Stinson,

Ma,

Lai

et al. 2024

Appl Microbiol Biotechnol

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Donor human milk (DHM) provides myriad nutritional and immunological benefits for preterm and low birthweight infants. However, pasteurization leaves DHM devoid of potentially beneficial milk microbiota. In the present study, we performed milk microbiome transplantation from freshly collected mother’s own milk (MOM) into pasteurized DHM. Small volumes of MOM (5%, 10%, or 30% v/v) were inoculated into pasteurized DHM and incubated at 37 °C for up to 8 h. Further, we compared microbiome recolonization in UV-C-treated and Holder-pasteurized DHM, as UV-C treatment has been shown to conserve important biochemical components of DHM that are lost during Holder pasteurization. Bacterial culture and viability-coupled metataxonomic sequencing were employed to assess the effectiveness of milk microbiome transplantation. Growth of transplanted MOM bacteria occurred rapidly in recolonized DHM samples; however, a greater level of growth was observed in Holder-pasteurized DHM compared to UV-C-treated DHM, potentially due to the conserved antimicrobial properties in UV-C-treated DHM. Viability-coupled metataxonomic analysis demonstrated similarity between recolonized DHM samples and fresh MOM samples, suggesting that the milk microbiome can be successfully transplanted into pasteurized DHM. These results highlight the potential of MOM microbiota transplantation to restore the microbial composition of UV-C-treated and Holder-pasteurized DHM and enhance the nutritional and immunological benefits of DHM for preterm and vulnerable infants. Key points • Mother’s own milk microbiome can be successfully transplanted into donor human milk. • Recolonization is equally successful in UV-C-treated and Holder-pasteurized milk. • Recolonization time should be restricted due to rapid bacterial growth. Graphical Abstract

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Improved outcomes of feeding low birth weight infants with predominantly raw human milk versus donor banked milk and formula

Abstract: Feeding predominantly with mother's raw milk seems to result in optimal neonatal outcomes.

Cited by 37 publications

References 47 publications

Human Milk Banking: a bridge between the preterm mother and infant; the experience from a Greek Public Perinatal Center

Human Milk Banking: a bridge between the preterm mother and infant; the experience from a Greek Public Perinatal Center

Comparative effectiveness of liquid human milk fortifiers: A systematic review and meta‐analysis

Milk microbiome transplantation: recolonizing donor milk with mother's own milk microbiota

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