Improved Outcome of Staphylococcus aureus Bacteremia

Staphylococcus aureus Bacteremia: Predictors of 30-Day Mortality in a Large Cohort

“…Several studies [16][17][18][19][20][21][22][23][24] published in the 1990s have identified risk factors for mortality among patients with SAB. Factors previously found to be significantly associated with mortality include older age [17,23], source of SAB [17,22], presence of shock [17,22], SAB caused by MRSA [18,22], presence of meningitis [18], inadequate treatment [18], acute severity of illness at onset of SAB [19,20], and underlying disease status [20,24].…”

“…Factors previously found to be significantly associated with mortality include older age [17,23], source of SAB [17,22], presence of shock [17,22], SAB caused by MRSA [18,22], presence of meningitis [18], inadequate treatment [18], acute severity of illness at onset of SAB [19,20], and underlying disease status [20,24]. What is striking is the variability in risk factors identified among these studies [16][17][18][19][20][21][22][23][24]. In our opinion this variability is primarily due to 3 factors.…”

“…In addition, S. aureus has a propensity to produce metastatic infection when it invades the bloodstream [4]. Osteomyelitis, endocarditis, and septic arthritis are the most common metastatic infections related to SAB.In the past decade studies of SAB have focused primarily on 3 areas: iv catheter-related SAB [1,[5][6][7][8][9], the risk of infectious endocarditis among various populations with SAB [10][11][12][13][14][15], and factors predictive of mortality [16][17][18][19][20][21][22][23][24]. The study presented in this report focused on factors predictive of mortality among patients with SAB.…”

“…The study presented in this report focused on factors predictive of mortality among patients with SAB. Among previously published studies [16][17][18][19][20][21][22][23][24], there has been considerable variation in the factors found to be predictive of mortality related to SAB.…”

Impact of Methicillin Resistance on the Outcome of Patients With Bacteremia Caused by Staphylococcus aureus

“…Crude in-hospital mortality in patients with bacteremia due to MRSA was 36%, a rate similar to that in previous reports. 5,7,9,39,40 Mortality as high as 60% in patient populations with more severe underlying diseases or for nosocomial infections only has been reported. 3,4,10,41 The in-hospital mortality for patients with MSSA bacteremia was 27% (40 deaths in 145 patients), consistent with that of other series.…”