Improved outcome at 10 years for serous-papillary/clear cell or high-risk endometrial cancer patients treated by adjuvant high-dose whole abdomino-pelvic irradiation

Uterine papillary serous cancer: A review of the literature

“…Given the propensity UPSC has to recur within the peritoneal cavity, studies of radiation therapy in the management of this disease have explored the role of whole abdominal radiotherapy with a pelvic boost (WAPI) [125][126][127][128][129][130]. In a study of 60 patients with surgically staged I UPSC, adjuvant therapy was given in the form of radiation (n= 12, 20%), chemotherapy (n= 7, 12%), combination chemotherapy and radiation therapy (n=1, 2%) and observation alone (n= 40, 66%) [109].…”

“…In a prospective, non-randomized study of 24 women treated with WAPI for optimally cytoreduced (b2 cm residual disease) stage III UPSC or clear cell EC, 5-year cause-specific survival was 62% [127]. Chronic, grade 3-4 gastrointestinal toxicity was reported in 14% of patients [127].…”

“…In a prospective, non-randomized study of 24 women treated with WAPI for optimally cytoreduced (b2 cm residual disease) stage III UPSC or clear cell EC, 5-year cause-specific survival was 62% [127]. Chronic, grade 3-4 gastrointestinal toxicity was reported in 14% of patients [127]. In another prospective study, carried out by the GOG, of adjuvant WAPI in women with optimally cytoreduced (b 2 m residual disease) stage III/IV UPSC, 8 out of 20 treated patients died of disease between 9.6 and 35.2 months following diagnosis [133].…”

Clinical Applications of Volumetric Modulated Arc Therapy

“…Our conventional technique is an anteroposterior/posteroanterior beam arrangement with blocks for the liver and kidneys (14,15). With this technique, a large amount of bone marrow receives the full dose.…”

Economic Evaluation of Hormonal Therapies for Postmenopausal Women with Estrogen Receptor–Positive Early Breast Cancer in Canada

“…The risk of death from fracture in the 1 year after the fracture was estimated to be 22% based on a systematic review of prospective and retrospective studies of 64,316 patients after hip fracture surgery [20][21][22] . An endometrial cancer mortality rate of 3% was obtained from a 10-year prospective trial of patients with stages i-iii endometrial carcinoma 23,24 . No excess mortality risk accrues to arthralgia or myalgia; age-specific mortality rates for Canadian females were therefore used for those aes.…”