Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system

Hou, Jian; Sun, E; Sun, Congyong; Wang, Jing; Yang, Lei; Jia, Xiao‐Bin; Zhang, Zhenhai

doi:10.1016/j.ijpharm.2016.08.045

Cited by 75 publications

(36 citation statements)

References 27 publications

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“…In addition to the thermothickening effect studied, soluplus can increase the equilibrium solubility of poorly water‐soluble drugs relevant to topical drug delivery, including estradiol, clotrimazole, and itraconazole . It has also been shown to enhance intestinal absorption in dogs and rats, and thus improve bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Soluplus solutions as thermothickening materials for topical drug delivery

Cook

Shamat

2018

J of Applied Polymer Sci

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Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have application topical drug delivery to sites including the skin, vagina, rectum or nasal mucosa, where the increase in viscosity allows for improved retention. However, there exists very little information surrounding this “thermothickening” phenomenon and the effect of solution composition on temperature‐dependent rheology. In this study, the effect of soluplus concentration, salt inclusion, ethanol addition, and pH on temperature‐dependent rheology was measured. The rheology of the solutions was unaffected by pH over the range tolerated by the skin (pH 4–7), but the inclusion of ethanol rapidly negated the thermothickening effect. “Salting out” of the solutions resulted in a depression of gelation temperatures, and an increase in both storage and loss moduli of the solutions. 30% (w/v) soluplus in 1 M NaCl or KCl was identified as a potential thermothickening agent for topical drug delivery. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46915.

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Section: Discussionmentioning

confidence: 99%

Soluplus solutions as thermothickening materials for topical drug delivery

Cook

Shamat

2018

J of Applied Polymer Sci

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“…34 TPGS and P105 were dissolved in a ethanol and then combined with OA powder to evaporate in a rotary evaporator. During this process, OA and TPGS/P105 self-assembled into micelles, which encapsulated OA in the core part.…”

Section: Preparation and Characterization Of The Oa-micellesmentioning

confidence: 99%

Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/D-α-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment

Wu¹,

Zhong

et al. 2016

IJN

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“…The rats were randomly divided into four groups (6 animals each). The dosages of taxanes used in the pharmacokinetic study were based on the previously published reports [15][16][17] . For solution, T-13 and T-26 were dissolved in a mixture of Tween 80 and ethanol (50:50, v/v) at 50 mg/mL for intravenous and oral administration, respectively.…”

Section: Administration Of T-13 and T-26 To Ratsmentioning

confidence: 99%

T-13 and T-26, the novel taxanes with improved oral bioavailability in rats

Yue

Zhou

Wang

2020

Sci Rep

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www.nature.com/scientificreports www.nature.com/scientificreports/ half-life of the terminal phase (t 1/2 ) and the mean residence time (MRT). Other parameters such as maximum plasma concentration (C max ) and the time to reach C max (T max ) were also analyzed after oral administration in rats. Statistical analysis.The data were presented as mean ± standard deviation of at least three experiments.The Mann-Whitney U-test was used to investigate statistical differences at a significance level of P < 0.05. All data processing was performed using the statistical package for social sciences (SPSS) software. ResultsThe mean plasma concentration-time profiles and the pharmacokinetic parameters of T-13 and T-26 after intravenous (5 mg/kg) and oral administration (60 mg/kg) in rats were presented in Fig. 2 and Table 1, respectively. As reflected in Table 1, T-13 and T-26 displayed similar values and demonstrated a higher capacity to promote the absorption in vivo. Finally, the oral bioavailability of T-13 and T-26 were calculated to be 10.71% and 65.79%, respectively, which were both higher than 5% for paclitaxel 15 . Scientific RepoRtS |(2020) 10:3211 | https://doi.

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Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system

Cited by 75 publications

References 27 publications

Soluplus solutions as thermothickening materials for topical drug delivery

Soluplus solutions as thermothickening materials for topical drug delivery

Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/D-α-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment

T-13 and T-26, the novel taxanes with improved oral bioavailability in rats

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Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system

Cited by 75 publications

References 27 publications

Soluplus solutions as thermothickening materials for topical drug delivery

Soluplus solutions as thermothickening materials for topical drug delivery

Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/D-&alpha;-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment

T-13 and T-26, the novel taxanes with improved oral bioavailability in rats

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Product

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Preparation and antitumor evaluation of self-assembling oleanolic acid-loaded Pluronic P105/D-α-tocopheryl polyethylene glycol succinate mixed micelles for non-small-cell lung cancer treatment