Improved Nasal Bioavailability of FITC-Dextran (<i>M</i><sub>w</sub>4300) from Mucoadhesive Microspheres in Rabbits

El-Shafy, Mohammed Abd; Kellaway, I.W.; Taylor, Glyn; Dickinson, Paul

doi:10.3109/10611869909085518

Cited by 23 publications

(9 citation statements)

References 18 publications

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“…Different methods have been tried by various researchers to prepare chitosan microspheres, e.g. ionotropic gelation [25], emulsification-crosslinking [18,26], thermal crosslinking [6], solvent evaporation [27], spray drying [16,28] and precipitation coacervation [29].…”

Section: Introductionmentioning

confidence: 99%

Chitosan microspheres as a delivery system for nasal insufflation

Patil¹,

Sawant

2011

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Chitosan microspheres as a delivery system for nasal insufflation

Patil¹,

Sawant

2011

Colloids and Surfaces B: Biointerfaces

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“…In conclusion, these results indicate that the chitosan microspheres have potential to deliver AB following intranasal administration. Its possibility to avoid first pass metabolism of AB may ultimately show improvement of bioavailability than oral dosage, probably as a consequence of prolonged residence at the absorption site 18 .…”

Section: Resultsmentioning

confidence: 99%

Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration

Patil¹,

Murthy

2006

Indian J Pharm Sci

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Mucoadhesive chitosan microspheres of amlodipine besylate were prepared for nasal administration with the aim of avoiding the first pass effect. A series of batches of microspheres were prepared by simple emulsification crosslinking method to optimize parameters like external phase (mixture of heavy and light liquid paraffin in the ratio of 1:1), stirring rate (1200 rpm), dioctyl sodium sulfosuccinate concentration (0.2% w/v), Chitosan:drug ratio (2:1), volume of crosslinking agent (glutaraldehyde, 1 ml) and time of crosslinking (3 h). The microspheres were evaluated for physical characteristics such as particle size, particle shape and surface morphology by scanning electron microscopy, drug entrapment efficiency, in vitro mucoadhesion, and in vitro drug release characteristics. The microspheres had a mean particle size of 36.47+3.39 µ µ µ µ µm, suitable for nasal administration. Electron microscopy revealed that microspheres were spherical with nearly smooth surface morphology. Application of in vitro drug release data to various kinetic equations indicated matrix diffusion controlled drug release from chitosan microspheres.

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“…Microspheres have also been investigated as vehicles for nasal delivery of larger molecules, such as peptides and proteins. An increased bioavailability of FITC-dextran (MW 4300) was observed in rats when microspheres made from carbopol were used as a vehicle in comparison with reference lactose microspheres (Abd El-Shafy et al 2000). A significantly greater hypocalcaemic effect was observed after administration of salmon calcitonin in gelatin microspheres in comparison with salmon calcitonin in buffer (Morimoto et al 2001).…”

Section: The Nasal Routementioning

confidence: 99%

Pharmaceutical applications of mucoadhesion for the non-oral routes

Edsman

Hägerström

2005

Journal of Pharmacy and Pharmacology

152

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The adhesion of pharmaceutical formulations to the mucosal tissue offers the possibility of creating an intimate and prolonged contact at the site of administration. This prolonged residence time can result in enhanced absorption and, in combination with a controlled release of the drug, also improved patient compliance by reducing the frequency of administration. During the almost 30 years over which mucoadhesion has been studied, a considerable amount of knowledge has been gained, and much has been learned about the different mechanisms occurring at the formulationmucus interface and the properties that affect these mechanisms. The in-vivo performance of a dosage form not only depends on the mechanisms occurring at the interface, but also on the properties of the total mucoadhesive complex: the dosage form, the mucosa and the interface between them. A wide variety of methods are used for studying mucoadhesion; some rather similar to the in-vivo situation and some mimicking the interface alone. In this review, the mucus surface, the methods used for the study of mucoadhesion, the different mechanisms involved in mucoadhesion and theories underpinning them have been described. The complexity of mucoadhesion when trying to systemize the subject will also be discussed. The last part of the review describes the buccal, nasal, ocular, vaginal and rectal routes and provides examples of what can be achieved in-vivo when using mucoadhesive formulations.

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Improved Nasal Bioavailability of FITC-Dextran (M_w4300) from Mucoadhesive Microspheres in Rabbits

Cited by 23 publications

References 18 publications

Chitosan microspheres as a delivery system for nasal insufflation

Chitosan microspheres as a delivery system for nasal insufflation

Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration

Pharmaceutical applications of mucoadhesion for the non-oral routes

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Improved Nasal Bioavailability of FITC-Dextran (Mw4300) from Mucoadhesive Microspheres in Rabbits

Cited by 23 publications

References 18 publications

Chitosan microspheres as a delivery system for nasal insufflation

Chitosan microspheres as a delivery system for nasal insufflation

Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration

Pharmaceutical applications of mucoadhesion for the non-oral routes

Contact Info

Product

Resources

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Improved Nasal Bioavailability of FITC-Dextran (M_w4300) from Mucoadhesive Microspheres in Rabbits