Improved multiorgan function after prolonged univentricular support

Renal Failure in Patients with Left Ventricular Assist Devices

“…In most of these studies, improvement in renal function to "normal" values (serum creatinine 1.0-1.3 mg/dl) was demonstrated in patients when pre-existing RD was mild to moderate (serum creatinine 1.4-1.9 mg/dl), regardless of whether a pulsatile or continuousflow LVAD was implanted (17,27,45,46,50,60). In addition, several studies have demonstrated dramatic improvements in renal function after LVAD implantation in patients with baseline creatinine values of 3.1-4.1 mg/dl and even in those dependent on CRRT before LVAD implantation (23,27,47,58,(61)(62)(63)(64).…”

International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children

“…End-organ function may be preserved, or perturbations in function may reverse with improved perfusion, thus improving transplant suitability and outcome. 153 Therapeutic Recommendations. Recommendation 37: Institution of mechanical cardiac support should be considered in patients without structural congenital heart disease, who manifest acute low cardiac output or who have intractable arrhythmias during a presumably temporary condition that is refractory to medical therapy (HF Stage D) such as myocarditis, septic shock, or acute rejection following cardiac transplantation.…”

Incidence and Patterns of Adverse Event Onset During the First 60 Days After Ventricular Assist Device Implantation

“…Once supported, patients have resolution of their heart failure state, improved survival to transplantation, and enhanced quality of life and functional status [1–3,12–18]. Continued developments in VAD technology and increasing clinical experience with VADs have resulted in improved patient outcomes over time [11,19–23].…”