Improved mouse sciatic nerve regeneration following lymphocyte cell therapy

Bombeiro, André Luís; Lima, Bruno Henrique de Melo; Bonfanti, Amanda Pires; Oliveira, Alexandre Leite Rodrigues de

doi:10.1016/j.molimm.2020.03.003

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…During the early phase, the nerve fiber rapidly disassembles. However, the nerve fiber can regenerate, although the neurons are unable to regenerate, or they tend to regenerate extremely slowly (14). In this study, we found that the recurrence rate was significantly different in the 2 groups (P < 0.05).…”

Section: Discussionmentioning

confidence: 56%

Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study

Wang

et al. 2021

Pain Phys

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BACKGROUND: Radiofrequency thermocoagulation through the supraorbital foramen with a different puncture method is a new approach for the treatment of ophthalmic division trigeminal neuralgia. OBJECTIVES: To compare the efficacy of the vertical puncture method and the transverse puncture method in the treatment of ophthalmic division trigeminal neuralgia during radiofrequency thermocoagulation through the supraorbital foramen. STUDY DESIGN: Randomized, longitudinal prospective, clinical research study. SETTING: Department of Anesthesiology and Pain Medicine, Jiaxing, China. METHODS: A total of 57 patients with ophthalmic division trigeminal neuralgia were enrolled in the study between October 2011 and April 2018, and prospectively randomized into the vertical puncture group (n = 29) or transverse puncture group (n = 28). All these patients received computed tomography guided radiofrequency thermocoagulation through the supraorbital foramen. Patients in the vertical puncture group were treated with a vertical puncture method; patients in the transverse puncture group received a transverse puncture method. Facial pain was evaluated using the Numeric Rating Scale preoperatively and at 1 day, 6 months, 1 year, and 2 years after treatment; facial numbness degree was analyzed at 1 day and 2 years after the treatments were recorded. The short-term and long-term complications during the period of postoperative follow-up were recorded. RESULTS: All surgical procedures were successfully completed. The Numeric Rating Scale scores at 6 months, 1 year, and 2 years after the treatment were significantly lower in the transverse puncture group compared to the vertical puncture group (P < 0.05), while no difference was observed on day one after the treatment (P > 0.05). The numbness degree at 2 years was significantly decreased compared to day one in both groups (P < 0.05). The radiofrequency thermocoagulation for ophthalmic division trigeminal neuralgia in the transverse puncture group showed better long-term outcomes than those in the vertical puncture group (P < 0.05). No short-term or long-term postoperative complications were observed in any of the groups. LIMITATIONS: Additional clinical data should be collected to preserve the results in future work. CONCLUSION: The transverse puncture method during radiofrequency thermocoagulation through the supraorbital foramen had better efficacy and fewer complications in comparison with the vertical puncture method when treating ophthalmic division trigeminal neuralgia. KEY WORDS: Trigeminal neuralgia, radiofrequency thermocoagulation, supraorbital foramen

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Section: Discussionmentioning

confidence: 56%

Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study

Wang

et al. 2021

Pain Phys

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“…As expected, nocodazole treatment not only inhibited WD but also attenuated post-PNI morphologic and functional regeneration. WD is essential for nerve regeneration, as the debris of degenerated axons and myelin needs to be cleaned up as quickly as possible to create a favorable microenvironment for promoting subsequent nerve regeneration (Bombeiro et al, 2020). Although the deeper underlying mechanisms require further investigation, the results from the present study suggest that microtubule stabilization may be conducive to peripheral nerve regeneration, due at least in part to the role of this process in WD.…”

Section: Discussionmentioning

confidence: 67%

Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury

Liu

Zou

et al. 2022

Neural Regen Res

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“…IL-17F is a pro-inflammatory effector together with IL-17A produced by Th17 cells [ 40 ]. It is reported that the Th17 cell frequency was increased in the regenerated nerve after mice sciatic nerve crush [ 3 ]. Moreover, T cells were found invaded into dorsal root ganglia after peripheral nerve lesions [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

IL-17F depletion accelerates chitosan conduit guided peripheral nerve regeneration

Chen

Liu

Zhang

et al. 2021

acta neuropathol commun

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Peripheral nerve injury is a serious health problem and repairing long nerve deficits remains a clinical challenge nowadays. Nerve guidance conduit (NGC) serves as the most promising alternative therapy strategy to autografts but its repairing efficiency needs improvement. In this study, we investigated whether modulating the immune microenvironment by Interleukin-17F (IL-17F) could promote NGC mediated peripheral nerve repair. Chitosan conduits were used to bridge sciatic nerve defect in IL-17F knockout mice and wild-type mice with autografts as controls. Our data revealed that IL-17F knockout mice had improved functional recovery and axonal regeneration of sciatic nerve bridged by chitosan conduits comparing to the wild-type mice. Notably, IL-17F knockout mice had enhanced anti-inflammatory macrophages in the NGC repairing microenvironment. In vitro data revealed that IL-17F knockout peritoneal and bone marrow derived macrophages had increased anti-inflammatory markers after treatment with the extracts from chitosan conduits, while higher pro-inflammatory markers were detected in the Raw264.7 macrophage cell line, wild-type peritoneal and bone marrow derived macrophages after the same treatment. The biased anti-inflammatory phenotype of macrophages by IL-17F knockout probably contributed to the improved chitosan conduit guided sciatic nerve regeneration. Additionally, IL-17F could enhance pro-inflammatory factors production in Raw264.7 cells and wild-type peritoneal macrophages. Altogether, IL-17F may partially mediate chitosan conduit induced pro-inflammatory polarization of macrophages during nerve repair. These results not only revealed a role of IL-17F in macrophage function, but also provided a unique and promising target, IL-17F, to modulate the microenvironment and enhance the peripheral nerve regeneration.

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Improved mouse sciatic nerve regeneration following lymphocyte cell therapy

Cited by 17 publications

References 31 publications

Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study

Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study

Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury

IL-17F depletion accelerates chitosan conduit guided peripheral nerve regeneration

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