Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole

Kim, Geon Min; Sohn, Hee Ju; Choi, Won Seok; Sohn, Uy Dong

doi:10.4196/kjpp.2021.25.6.507

Cited by 3 publications

(1 citation statement)

References 51 publications

(64 reference statements)

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“…The calculation of the gastric emptying (GE) and GC of distribution of phenol red was performed as reported previously [ 39 , 40 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway

Duan,

Cai,

et al. 2024

Chin Med

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Background Postoperative ileus (POI) is a common obstruction of intestinal content passage caused by almost all abdominal operations that seriously strokes the quality of life of patients. Kuanchang-Shu granule (KCSG), a classic modified prescription based on “Da-Cheng-Qi Decoction”, has obtained satisfactory efficacy in the clinical therapeutics of POI. However, its material basis and holistic molecular mechanism against POI have not been revealed. Methods The chemical ingredients of KCSG were first characterized by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Subsequently, an integration strategy of the network pharmacology and molecular docking based on above identified ingredients was performed to unveil the potential targets involved in the treatment of KCSG on POI. Finally, intestinal manipulation induced rat POI model was constructed to verify the efficacy and predicted mechanism of KCSG against POI. Results In total, 246 ingredients mainly including organic acids, flavonoids, quinones, alkaloids, terpenoids, phenylpropanoids and phenols were identified. 41 essential ingredients, 24 crucial targets as well as 15 relevant signaling pathways were acquired based on network pharmacology analysis. Pharmacodynamic research showed that KCSG treatment could protect intestinal histological damage, promote the recovery of measurement of gastrointestinal transit disorder and inhibit the secretion of myeloperoxidase in the distal ileum tissues. The up-regulated expression of p-AKT and down-regulated expression of p-eNOS and HSP9OAA1 predicted by molecular docking and validated by western blotting showed that AKT/eNOS/HSP90AA1 pathway may be one of the crucial mechanisms that mediates the protective effect of KCSG.

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“…The calculation of the gastric emptying (GE) and GC of distribution of phenol red was performed as reported previously [ 39 , 40 ].…”

Section: Methodsmentioning

confidence: 99%

Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway

Duan,

Cai,

et al. 2024

Chin Med

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Prenatal exposure to corn oil, CMC-Na or DMSO affects physical development and multi-organ functions in fetal mice

Chen

et al. 2023

Reproductive Toxicology

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Atractylenolide I improves intestinal function, inflammatory response, bacterial translocation, and intestinal barrier function in postoperative ileus rats

Wang,

Zhou

2024

WCJD

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Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole

Cited by 3 publications

References 51 publications

Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway

Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway

Prenatal exposure to corn oil, CMC-Na or DMSO affects physical development and multi-organ functions in fetal mice

Atractylenolide I improves intestinal function, inflammatory response, bacterial translocation, and intestinal barrier function in postoperative ileus rats

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