Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment

Mitxelena-Iribarren, Oihane; Zabalo, Jon; Arana, Sergio; Mujika, Maite

doi:10.1016/j.bios.2018.09.001

Cited by 39 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the flow state of the fluid on microfluidic device is different from that of the turbulence in large-scale channels, its laminar flow state and mass transfer is completely dependent on diffusion [134]. Therefore, the mixing step on chip often needs external mechanism, such as electrokinetic [135,136], magnetic [137,138] and the special design of channel geometry mentioned above [139], and often lacks the dynamic control of fluid interface. Under this premise, the combination of hydrodynamic focusing (HF) device and microfluidic chip can be a good choice for the synthesis of NPs.…”

Section: The Preparation Of Nano-drugsmentioning

confidence: 99%

“…Using microfluidic device for preclinical evaluation of NPs has also shown advantages. The special design of channel geometry (such as line and cross shape microstructure) and highly controlled fluidics provides a high fluid mixing and avoids pure laminar flow and NPs sedimentation, thus increasing the internalization of NPs by the cells [139]. Because of the enhanced permeability and retention (EFR) effect, NPs often accumulate in tumors.…”

Section: The Preparation Of Nano-drugsmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional microfluidic chip for cancer diagnosis and treatment

Guo¹,

Zhang²,

Liu³

et al. 2021

Nanotheranostics

View full text Add to dashboard Cite

Microfluidic chip is not a chip in the traditional sense. It is technologies that control fluids at the micro level. As a burgeoning biochip, microfluidic chips integrate multiple disciplines, including physiology, pathology, cell biology, biophysics, engineering mechanics, mechanical design, materials science, and so on. The application of microfluidic chip has shown tremendous promise in the field of cancer therapy in the past three decades. Various types of cell and tissue cultures, including 2D cell culture, 3D cell culture and tissue organoid culture could be performed on microfluidic chips. Patient-derived cancer cells and tissues can be cultured on microfluidic chips in a visible, controllable, and high-throughput manner, which greatly advances the process of personalized medicine. Moreover, the functionality of microfluidic chip is greatly expanding due to the customizable nature. In this review, we introduce its application in developing cancer preclinical models, detecting cancer biomarkers, screening anti-cancer drugs, exploring tumor heterogeneity and producing nano-drugs. We highlight the functions and recent development of microfluidic chip to provide references for advancing cancer diagnosis and treatment.

show abstract

Section: The Preparation Of Nano-drugsmentioning

confidence: 99%

Section: The Preparation Of Nano-drugsmentioning

confidence: 99%

Multifunctional microfluidic chip for cancer diagnosis and treatment

Guo¹,

Zhang²,

Liu³

et al. 2021

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…The efficiency of NP-encapsulated anti-cancer drugs has been shown to be much higher than free drug, both of which could be enhanced when tested in microfluidics. Recently, Mitxelena-Iribarren et al found that adding microstructures within the microfluidic chamber could increase the medium mixing and reduce NP retention compared with pure laminar flow [133] (Figure 3c). Different sizes of cross shape and linear microstructures with a height of about 30 µm were embedded at the microfluidic chamber.…”

Section: Key Microfluidic Models For Np Evaluationmentioning

confidence: 99%

“…Finally, new microfluidic systems targeting at parallel testing of multiple drugs or cell types towards personalized medicine and treatment are being developed as well. These systems include single-cell-based assays [164], 2D cell monolayers [133,165] and 3D tumor spheroids [166,167,168]. At the same time, by integrating different sensors and imaging systems, microfluidic systems are ready for monitoring NP-induced cell and tissue changes optically, physically and biochemically in a noninvasive way [169].…”

Section: Key Microfluidic Models For Np Evaluationmentioning

confidence: 99%

Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems

Zhu

Long

et al. 2019

Micromachines

View full text Add to dashboard Cite

Nanoparticles (NPs) have found a wide range of applications in clinical therapeutic and diagnostic fields. However, currently most NPs are still in the preclinical evaluation phase with few approved for clinical use. Microfluidic systems can simulate dynamic fluid flows, chemical gradients, partitioning of multi-organs as well as local microenvironment controls, offering an efficient and cost-effective opportunity to fast screen NPs in physiologically relevant conditions. Here, in this review, we are focusing on summarizing key microfluidic platforms promising to mimic in vivo situations and test the performance of fabricated nanoparticles. Firstly, we summarize the key evaluation parameters of NPs which can affect their delivery efficacy, followed by highlighting the importance of microfluidic-based NP evaluation. Next, we will summarize main microfluidic systems effective in evaluating NP haemocompatibility, transport, uptake and toxicity, targeted accumulation and general efficacy respectively, and discuss the future directions for NP evaluation in microfluidic systems. The combination of nanoparticles and microfluidic technologies could greatly facilitate the development of drug delivery strategies and provide novel treatments and diagnostic techniques for clinically challenging diseases.

show abstract

“…Lung, prostate, colorectal, stomach, and liver cancers are the most common types of cancer among men, while breast, colorectal, lung, cervical, and thyroid cancers are the most common in women [1]. It has been estimated that by the year 2050, 27 million new cancer cases will be diagnosed [2]. Currently, cancer treatment involves surgery, chemotherapy, radiotherapy, immunotherapy, hormone therapy, and other targeted therapies, with chemotherapy playing a central role.…”

Section: Introductionmentioning

confidence: 99%

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Tadini‐Buoninsegni

Palchetti

2020

Sensors

View full text Add to dashboard Cite

Cancer is a multifactorial family of diseases that is still a leading cause of death worldwide. More than 100 different types of cancer affecting over 60 human organs are known. Chemotherapy plays a central role for treating cancer. The development of new anticancer drugs or new uses for existing drugs is an exciting and increasing research area. This is particularly important since drug resistance and side effects can limit the efficacy of the chemotherapy. Thus, there is a need for multiplexed, cost-effective, rapid, and novel screening methods that can help to elucidate the mechanism of the action of anticancer drugs and the identification of novel drug candidates. This review focuses on different label-free bioelectrochemical approaches, in particular, impedance-based methods, the solid supported membranes technique, and the DNA-based electrochemical sensor, that can be used to evaluate the effects of anticancer drugs on nucleic acids, membrane transporters, and living cells. Some relevant examples of anticancer drug interactions are presented which demonstrate the usefulness of such methods for the characterization of the mechanism of action of anticancer drugs that are targeted against various biomolecules.

show abstract

Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment

Cited by 39 publications

References 31 publications

Multifunctional microfluidic chip for cancer diagnosis and treatment

Multifunctional microfluidic chip for cancer diagnosis and treatment

Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Contact Info

Product

Resources

About