Improved Micellar Dispersal of Dietary Lipid by Bile Acids during Replacement Therapy in Growth Hormone-deficient Children

Abstract

P e d i a t . R c s . 12: I 186-1 191 ( 1 0 7 7 ) Bile acids fat digestion g r o w t h h o r m o n e

Hyperbilirubinaemia and Idiopathic Hypopituitarism in the Newborn Period

“…Hypothyroidism secondary to TSH deficiency results in elevation of indirect bilirubin levels due to failure of conjugation in the absence of increased hemolysis. Corticosteroids have been reported to increase the enterohepatic circulation of bile salts (17). * Performed in J. M .…”

Neonatal cholestasis in congenital pituitary hormone deficiency and isolated hypocortisolism: characterization of liver dysfunction and follow-up

“…Since the initial report of CPHD in an infant with cholestasis and hypoglycemia by Blizzard and Alberts (7), several descriptions of case reports and few case series have been described. Although it is not exactly known how hormone deficiencies cause cholestasis, the evidence of clinical and some experimental data supports the role of pituitary trophic hormones (cortisol, GH and thyroid hormones) in the pathogenesis of this disorder (8)(9)(10)(11)(12)(13). Cortisol deficiency in adrenalectomized animals reduces biliary flow, which is reverted after treatment with hydrocortisone.…”

“…Cortisol deficiency in adrenalectomized animals reduces biliary flow, which is reverted after treatment with hydrocortisone. GH also modulates the biosynthesis and secretion of biliary acids, and it has been shown that biliary flow recovers after hydrocortisone and GH treatment (13)(14)(15). While there is not a pathognomonic biochemical pattern of liver dysfunction in relation to a particular hormone insufficiency, some reports have attempted to identify a pattern that leads towards this diagnosis.…”

“…The usual pattern described in CPHD is "giant cell hepatitis" (5,8,13,21). In our patients who showed physical findings consistent with hypopituitarism, liver biopsies were not carried out, assuming that the cholestasis was potentially a manifestation of hormone deficiencies (4,14,19).…”

Konnataler Panhypopituitarismus und Riesenzellhepatitis bei einem 3 Monate alten Säugling

“…Eine weitere Beobachtung an Ratten zeigt, dass Wachstumshormon die Gallensäuresynthese modulieren kann [2]. Unter hGH-Therapie kommt es zu vermehrten Gallesäuremizellen im Jejunum [15]. …”