Improved method for the synthesis of N-methyl-2-oxoalkanesulfonamides.

N‐Alkylsulfonylimines as Dipolarophiles in Cycloaddition Reactions

“…These compounds were first described by Atkins and Burgess in 1967, and their reaction with anilines and highly electron‐rich alkenes was reported 1. They are variously known throughout the literature as N ‐sulfonylamines,1 N ‐sulfonylalkylamines,2 N ‐alkylsulfonyl imides,3 and N ‐alkylsulfonylimines,4 and are not to be confused with N ‐sulfonylimines 3 .…”

Modular Synthesis of Alkenyl Sulfamates and β-Ketosulfonamides via Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry and Photomediated 1,3-Rearrangement

“…Typical syntheses of β-ketosulfonamides rely on a polar disconnection between a silyl enol ether, , or an enamine, and a sulfamoyl chloride reagent (Figure a). This approach requires the multistep preparation of highly reactive sulfamoyl chloride reagents that are generally sensitive to moisture and challenging to purify .…”