Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation. Part I: description of method and normal values obtained in healthy volunteers.

Meyer, John Stirling; Ishihara, Naoki; Deshmukh, Vinod D.; Naritomi, Hiroaki; Sakai, Fumihiko; Hsu, M C; Pollack, Phyllis

doi:10.1161/01.str.9.3.195

Cited by 142 publications

(42 citation statements)

References 24 publications

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“…Consistent with the finding of several other investigators, decreases in mixed cortical CBF did not extend to the distribution of the PCA (thalamus and occipital cortex) (Naritomi et al, 1978;Melamed et aI., 1980;Meyer et aI., 1981). It has been suggested that sparing of CBF within the dis tribution of the PCA with age is related in some way to the fact that the visual centers are located in this area (Naritomi et aI., 1978;Melamed et aI., 1980;Meyer et aI., 1981).…”

Section: Normative Datasupporting

confidence: 88%

CBF Measured by Xe-CT: Approach to Analysis and Normal Values

Yonas

Darby

Marks

et al. 1991

J Cereb Blood Flow Metab

123

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Summary:Normal reference values and a practical ap proach to CBP analysis are needed for routine clinical analysis and interpretation of xenon-enhanced computed tomography (CT) CBP studies. We measured CBP in 67 normal individuals with the GE 9800 CT scanner adapted for CBP imaging with stable Xe. CBP values for vascular territories were systematically analyzed using the cluster ing of contiguous 2-cm circular regions of interest (ROls) placed within the cortical mantle and basal ganglia. Mixed cortical flows averaged 51 ± 10 ml . 100 g -1 . min -1. High and low flow compartments, sampled by placing 5-mm circular ROIs in regions containing the highest and lowest

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Section: Normative Datasupporting

confidence: 88%

CBF Measured by Xe-CT: Approach to Analysis and Normal Values

Yonas

Darby

Marks

et al. 1991

J Cereb Blood Flow Metab

123

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“…Regional CBF (rCBF) was measured by the 133Xe in halation method (Meyer et al , 1978) modified after Obrist et al (1975). Briefly, 14 collimated, sodium iodide crystal scintillation detectors were mounted in radial array over both hemispheres including frontal, precentral, sylvian opercular, parietal, posterior, and inferior temporal and occipital regions.…”

Section: Measurement Of Regional Cbf By 133xe Inhalationmentioning

confidence: 99%

Cerebral Atrophy and Hypoperfusion Improve during Treatment of Wernicke-Korsakoff Syndrome

Meyer

Tanahashi

Ishikawa

et al. 1985

J Cereb Blood Flow Metab

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Nineteen patients with sudden onset of impaired recent memory, cerebellar ataxia, peripheral neuropathy, and other signs of Wernicke-Korsakoff syndrome (WKS) were treated and examined prospectively for 3 months. Serial studies included histories, neurological examinations, cognitive capacity screening examinations (CCSE), computed tomography (CT) scans, and measurements of regional CBF. Patients were detoxified and withdrawn from sedatives before CBF measurements were examined. Treatment included alcohol withdrawal, nutritious diet, and 300 mg thiamine daily. Before treatment CCSE scores and blood flow values of both white and gray matter were reduced, particularly within both temporoparietal regions. After treatment of compliant patients (n = 10), white and gray matter blood flow increased concurrently with improved CCSE scores. Abnormal eye signs, ataxia, peripheral neuropathy, and performance of activities of daily living also improved. Cerebral atrophy and ventricular enlargement measured by CT decreased. Early recognition and treatment of WKS in compliant patients permit rapid reversals of cognitive and neurological impairments associated with increased blood flow of gray and white matter and improvements of brain atrophy measured by CT scanning.

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“…3 -12 Mapping of actual isoresponse curves for 133 Xe in brain tissue immediately postmortem, in the present study, confirms the assumption that satisfactory gamma counts may be recorded from brain stem tissue as well as from the cerebellum by suitably collimated probes placed over the suboccipital area and directed toward the brain stem. 3 Radioactivity from hemispheric tissue counted by the probe directed toward the brain stem-cerebellar region was also shown to be relatively small when compared with that measured from tissues in the posterior fossa ( figs. 1, 2).…”

mentioning

confidence: 94%

133Xe inhalation method for measuring cerebral blood flow in conscious baboons.

Sakai¹,

Meyer²,

Yamaguchi³

et al. 1979

Stroke

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SUMMARY The non-invasive 133Xe inhalation method was modified to measure regional cerebral blood flow (rCBF) of both hemispheres and brain stem-cerebellar (BSC) regions in baboons to serve as a model for clarifying and validating human studies. Measurements were made in the alert, unanesthetized state at rest and during activation with spontaneous respiration in a primate chair or during sedation or anesthesia with mechanical respiration for direct comparison with the intra-arterial

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Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation. Part I: description of method and normal values obtained in healthy volunteers.

Cited by 142 publications

References 24 publications

CBF Measured by Xe-CT: Approach to Analysis and Normal Values

CBF Measured by Xe-CT: Approach to Analysis and Normal Values

Cerebral Atrophy and Hypoperfusion Improve during Treatment of Wernicke-Korsakoff Syndrome

133Xe inhalation method for measuring cerebral blood flow in conscious baboons.

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