Improved Metabolic Control in Insulin-Dependent Diabetes Mellitus With Insulin and Tolazamide

Efficacy of Sulfonylureas with Insulin in Type 2 Diabetes Mellitus

“…Similar extrapancreatic effects of sulfonylureas combined with insulin have been reported including studies using glycemic clamp techniques in patients with both varieties of diabetes. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Therefore, it is clear that sulfonylurea drugs also must possess insulin-sensitizing properties as reported with other well-accepted insulin-sensitizing agents, such as thiazolidinediones and metformin, and among sulfonylureas, glimepiride may have a greater insulin-sensitizing property. In the final analysis, adjunctive therapy with sulfonylureas consistently lowers the exogenous insulin dose and provides beneficial outcomes compared with insulin monotherapy.…”

Comparison of Morning or Bedtime Insulin With and Without Glyburide in Secondary Sulfonylurea Failure

“…Various studies show additive effects of these agents when used together (1)(2)(3)(4)(5)(6). Additional appropriate therapy for patients who have poor control using oral agents alone is still debated.…”

Adjunctive Use of Tolazamide in Newly-Diagnosed Diabetic Children

“…Despite some encouraging reports {Burke, Hartog and Waterfield 1984;Kabadi and Birkenholz 1988), the therapeutic worthiness of sulfonylureas in IDDM has been disputed. Ratzmann, Schulz, Heinke and Besch (1984) studied, with the use of a euglycemic clamp, the acute effects of tolbutamide on seven type I adult diabetics.…”

“…Contrasting studies have shown improved metabolic control with adjunctive use of oral sulfonylureas in only those diabetics with some endogenous insulin secretion (Burke, Hartog and Waterfield 1984). A recent study found im-proved metabolic control in long-standing Type I diabetics with the combination of tolazamide and insulin therapy when studied during a three month period (Kabadi and Birkenholz 1988). Nevertheless, most of the diabetic patients in these abovementioned studies were adults and, notably, were not recently diagnosed.…”