Improved lactose maldigestion by adaptation with lactulose crystals: Crossadapt study

Szilagyi, Andrew; Rivard, Julie

doi:10.1016/s0016-5085(00)85244-0

Cited by 2 publications

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“…While this difference may or may not be clinically significant at an individual level for lactose tolerance, it clearly allows demonstration of a population test effect on colonic microbial function. In fact, in our original abstract, six subjects already demonstrated a statistically significant trend at P=0.054 (25). Pearson correlation was used to compare symptoms with sum of breath H 2 .…”

Section: Statistical Analysis Student's Paired T Tests Were Used To Amentioning

confidence: 97%

Failure to Improve Parameters of Lactose Maldigestion using the Multiprobiotic Product VSL3 in Lactose Maldigesters: A Pilot Study

Yesovitch¹,

Cohen²,

Szilagyi³

2004

Canadian Journal of Gastroenterology

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Lactose maldigestion is a common genetic trait in up to 70% of the world's population. In these subjects, the ingestion of lactose may lead to prebiotic effects which can be confirmed by measurement of breath hydrogen. After a period of continuous lactose ingestion, colonic bacterial adaptation is measurable as improved parameters of lactose digestion. There may be inherent benefits in this process of adaptation which may protect against some diseases. We attempt to link therapeutically beneficial probiotics (VSL3, Seaford Pharmaceuticals Inc, Ontario) with improvement in parameters of lactose maldigestion. Two groups of five subjects with maldigestion were fed one or four packets of VSL3 (one packet containing 450 x 10(9) live bacteria) before testing and then 17 days later. A 50 g lactose challenge was carried out before and after feeding. While there was a trend toward increasing rather than reducing of summed breath hydrogen, no statistically significant changes were observed between results from before testing and those from testing 17 days later. The authors conclude that direct consumption of the probiotic VSL3 may not improve parameters of lactose maldigestion without metabolic activation. In its present format, therefore, the test for colonic adaptation cannot be used to demonstrate direct bacterial embedding with VSL3.

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Section: Statistical Analysis Student's Paired T Tests Were Used To Amentioning

confidence: 97%

Failure to Improve Parameters of Lactose Maldigestion using the Multiprobiotic Product VSL3 in Lactose Maldigesters: A Pilot Study

Yesovitch¹,

Cohen²,

Szilagyi³

2004

Canadian Journal of Gastroenterology

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“…This may account for the variable symptomatology and diminished responses to lactose challenge seen in chronic lactose intolerance. Some investigators have successfully exploited this phenomenon of adaptation and the theory of cross-adaptation by using lactulose therapy to attenuate symptoms due to lactase deficiency (91). The lowering of colonic pH that occurs with chronic (as little as 2 wk) lactose intake by a maldigester also plays a role in decreasing hydrogen production because it attenuates the bacterial response.…”

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confidence: 99%

Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation

Romagnuolo

Schiller

Bailey

2002

Am J Gastroenterology

238

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Breath tests are a simple and safe alternative to more invasive investigation strategies for many gastroenterological conditions. Both the hydrogen breath tests and the new 13C stable radioisotope breath tests are nonradioactive and safe in children and pregnancy. The range of diseases that can be identified include Helicobacter pylori infection, lactose and fructose intolerance, bacterial overgrowth, bile salt wastage, pancreatic insufficiency, liver dysfunction, and abnormal small bowel transit. In this review, the physiology supporting these tests and the principles of normal gas dynamics in the gut are briefly reviewed and then related to the test preparation and interpretation in two parts: 1) detection of H. pylori and 2) small bowel, pancreatic, and hepatobiliary disorders. A MEDLINE search reviewing all English language abstracts from 1966 to March, 2001 was performed, with an additional review of abstracts from major national meetings from 1997 to 2001. Using the information from this review, the performance characteristics of the various tests were detailed, and an attempt is made to provide some literature-based guidance regarding their indications and limitations. The interpretation of "flat" breath tests and the selective use of methane collection and colonic alkalinization are discussed. Breath tests are valuable tools that are, in general, underutilized in evaluating dyspepsia and functional bloating and diarrhea, as well as suspected malabsorption, including lactose intolerance.

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Improved lactose maldigestion by adaptation with lactulose crystals: Crossadapt study

Cited by 2 publications

References 0 publications

Failure to Improve Parameters of Lactose Maldigestion using the Multiprobiotic Product VSL3 in Lactose Maldigesters: A Pilot Study

Failure to Improve Parameters of Lactose Maldigestion using the Multiprobiotic Product VSL3 in Lactose Maldigesters: A Pilot Study

Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation

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