Improved IR780 derivatives bearing morpholine group as tumor-targeted therapeutic agent for near-infrared fluorescence imaging and photodynamic therapy

Mai, Yuhan; Qu, Xiaofang; Ding, Shangli; Lv, Jiajia; Li, Xinmin; Gao, Pengyuan; Liu, Yun; Yuan, Zeli

doi:10.1016/j.dyepig.2019.107979

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…One of the concerns of some of the presented PPG classes is that certain derivatives have been used for PDT. Cyanines, [145,146] halogenated BODIPY molecules [42] and some coumarin derivatives [147] are efficient PDT photosensitisers. While in the case of photoreleasing anticancer drugs this might even be an opportunity to provide an additional level of potency, in most applications this potential inherent phototoxicity is undesirable.…”

Section: Discussionmentioning

confidence: 99%

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

Josa-Culleré

Llebaría

2020

ChemPhotoChem

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Photopharmacological tools enable the precise spatiotemporal control of small molecule drugs. Amongst them, caged compounds incorporate a photolabile moiety which is released under illumination, thus liberating the active molecule. Caging groups have long been known and many chemical scaffolds have already been used in different applications. However, most of the initial examples are cleaved with UV light, which suffers from low tissue permeability and cell damage. Recently, caging groups that are released under visible light have been reported, which expand their utility. In this review, we outline the chemical strategies that have been used to increase the absorption wavelengths; we compare their photophysical properties, discuss their synthetic accessibility, and exemplify some of their biological applications.

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Section: Discussionmentioning

confidence: 99%

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

Josa-Culleré

Llebaría

2020

ChemPhotoChem

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“…In addition to PSs based on BODIPY skeleton, porphyrin, cyanine, naphthalimide, etc., also modified with a morpholine structure to make lysosome-targeted PSs. Their structures are shown in Figure b–d. − For AceDAN-H 2 Por-Lyso, the porphyrin structure cleverly introduced the 2-acetyl-6-dimethylaminonaphthalene (AceDAN) fluorophore with two-photon properties, resulting in AceDAN-H 2 Por-Lyso, which was used both for one-photon PDT, and two-photon PDT with deeper penetration depth. Modifying the skeleton of the PSs to improve their photostability and ROS generation is also a useful method to increase the therapeutic index .…”

Section: Lysosome-targeted Pssmentioning

confidence: 99%

“…Modifying the skeleton of the PSs to improve their photostability and ROS generation is also a useful method to increase the therapeutic index . The meso-chlorine was replaced by the N of the classic IR780 dye to enhance the photostability, and the oxygen-to-sulfur substitution of the naphthalimide increased the yield of ROS. , …”

Section: Lysosome-targeted Pssmentioning

confidence: 99%

Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Wang

Yoon

2021

ACS Appl. Mater. Interfaces

176

140

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Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.

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“…There are other nano-platforms that utilize polymers to make specific components or encapsulate them in a proper shell. For example, in 2017, Wang and co-workers [221] demonstrated an effective nanocarrier based on phospholipid/pluronic F68 complex nanocores and pullulan (polysaccharide) shells to carry IR780 (a near-infrared dye) [222,223] and paclitaxel (PTX) [224]. Additionally, pullulan acts as a natural ligand for the asialoglyco protein receptor (ASGPR) [224], which is often overexpressed by HCC cells.…”

Section: Application Of Polymers In Pdtmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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Improved IR780 derivatives bearing morpholine group as tumor-targeted therapeutic agent for near-infrared fluorescence imaging and photodynamic therapy

Cited by 12 publications

References 32 publications

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

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