Improved high-performance liquid chromatographic method for the determination of polycyclic aromatic hydrocarbon metabolites in human urine

Whiton, Robert S.; Witherspoon, Carlton L.; Buckley, Timothy J.

doi:10.1016/0378-4347(94)00537-f

Cited by 28 publications

(10 citation statements)

References 6 publications

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“…It is recommended that the more relevant parameter 3-hydroxybenzo(a)pyrene be measured speci®cally. Whiton et al (1995) determined the metabolite 3-hydroxybenz(a)anthracene in a collective of 14 persons not occupationally exposed to PAH. The mean value of 161 ng/l was about half as high as the mean value of 378 ng/g creat.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to polycyclic aromatic hydrocarbons in a fireproof stone producing plant: biological monitoring of 1-hydroxypyrene, 1-, 2-, 3- and 4-hydroxyphenanthrene, 3-hydroxybenz(a)anthracene and 3-hydroxybenzo(a)pyrene

Gündel

Schaller

Angerer

2000

International Archives of Occupational and Environmental Health

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In comparison with other industries, the internal PAH exposure at workplaces in a fireproof stone producing plant is high. This is probably caused by dermal PAH-absorption. Therefore, biological monitoring must be performed in the health surveillance of fireproof stone producing workers. The urinary PAH metabolites should be determined: 3-hydroxybenz(a)anthracene could probably be used as a biomarker representing the group of carcinogenic PAH.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to polycyclic aromatic hydrocarbons in a fireproof stone producing plant: biological monitoring of 1-hydroxypyrene, 1-, 2-, 3- and 4-hydroxyphenanthrene, 3-hydroxybenz(a)anthracene and 3-hydroxybenzo(a)pyrene

Gündel

Schaller

Angerer

2000

International Archives of Occupational and Environmental Health

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“…The intra-day R.S.D. of 3-OHBaP was relatively higher, indicating that the instability of 3-OHBaP in aqueous solution might be the major reason [7,27].…”

Section: Precisionmentioning

confidence: 93%

“…Simon et al [7] found that aqueous standard of 3-OHBaP was stable for 24 h at 4 • C if a methanol solution of Triton X100 R was added, then the recoveries of 3-OHBaP rose to 96%. Whiton et al also found that 3-OHBaP was not stable over time [27]. So further research is needed to improve the recovery.…”

Section: Recovery and Relative Standard Deviation (Rsd)mentioning

confidence: 94%

Fast simultaneous determination of urinary 1-hydroxypyrene and 3-hydroxybenzo[a]pyrene by liquid chromatography–tandem mass spectrometry

Fan

Dong

Zhang

et al. 2006

Journal of Chromatography B

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“…The advantage of this method is that it is not based exclusively on pyrene as the representative PAH compound, but takes into account exposure to a wide mixture of such compounds. [12][13][14] Nonetheless, enough data are not yet available to demonstrate convincingly the reliability of this method.…”

Section: Polycyclic Aromatic Hydrocarbons (Pahs)mentioning

confidence: 99%

Validity of Biomarkers in Environmental Health Studies: The Case of PAHs and Benzene

Dor¹,

Dab

Empereur‐Bissonnet

et al. 1999

Critical Reviews in Toxicology

114

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Exposure biomarkers, which have long been restricted to the framework of occupational hygiene, currently arouse increasing interest in the field of environmental pollution. To assess their validity, we propose here a conceptual framework that is based on their intrinsic characteristics and on properties related to the procedures for their analysis. The most important criteria are specificity for the toxic substance under consideration and sensitivity, that is, the ability to distinguish contrasted levels of exposure. Their analytic sensitivity and specificity are also important. Fulfilling these criteria is especially important in the context of environmental pollution, because the levels of exposure, and thus the contrasts, are low. This framework is used to assess the validity of some biomarkers for polycyclic aromatic hydrocarbons (1-hydroxypyrene and DNA adducts) and for benzene (urinary and serum benzene, trans,trans muconic acid, and S-phenylmercapturic acid). This evaluation shows that the most relevant biomarkers for estimating individual exposure to environmental pollution are 1-hydroxypyrene for polycyclic aromatic hydrocarbons and urinary benzene and S-phenylmercapturic for benzene.

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Improved high-performance liquid chromatographic method for the determination of polycyclic aromatic hydrocarbon metabolites in human urine

Cited by 28 publications

References 6 publications

Occupational exposure to polycyclic aromatic hydrocarbons in a fireproof stone producing plant: biological monitoring of 1-hydroxypyrene, 1-, 2-, 3- and 4-hydroxyphenanthrene, 3-hydroxybenz(a)anthracene and 3-hydroxybenzo(a)pyrene

Occupational exposure to polycyclic aromatic hydrocarbons in a fireproof stone producing plant: biological monitoring of 1-hydroxypyrene, 1-, 2-, 3- and 4-hydroxyphenanthrene, 3-hydroxybenz(a)anthracene and 3-hydroxybenzo(a)pyrene

Fast simultaneous determination of urinary 1-hydroxypyrene and 3-hydroxybenzo[a]pyrene by liquid chromatography–tandem mass spectrometry

Validity of Biomarkers in Environmental Health Studies: The Case of PAHs and Benzene

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