Improved healing of critical-size femoral defect in osteoporosis rat models using 3D elastin/polycaprolactone/nHA scaffold in combination with mesenchymal stem cells

Hejazi, Fatemeh; Ebrahimi, Vahid; Asgary, Mehrdad; Piryaei, Abbas; Fridoni, Mohammad Javad; Kermani, Ali A.; Zare, Fatemeh; Abdollahifar, Mohammad‐Amin

doi:10.1007/s10856-021-06495-w

Cited by 14 publications

(16 citation statements)

References 32 publications

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“…HA can influence the pH of the cariogenic biofilm, increasing it from 4.3 to 4.8. Apart from their use for mineralization enhancement, HA and CHA can also be used as buffering agents for organic acids [ 54 , 55 ].…”

Section: Hydroxyapatite For Btementioning

confidence: 99%

Bone Regeneration and Oxidative Stress: An Updated Overview

et al. 2022

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Bone tissue engineering is a complex domain that requires further investigation and benefits from data obtained over past decades. The models are increasing in complexity as they reveal new data from co-culturing and microfluidics applications. The in vitro models now focus on the 3D medium co-culturing of osteoblasts, osteoclasts, and osteocytes utilizing collagen for separation; this type of research allows for controlled medium and in-depth data analysis. Oxidative stress takes a toll on the domain, being beneficial as well as destructive. Reactive oxygen species (ROS) are molecules that influence the differentiation of osteoclasts, but over time their increasing presence can affect patients and aid the appearance of diseases such as osteoporosis. Oxidative stress can be limited by using antioxidants such as vitamin K and N‑acetyl cysteine (NAC). Scaffolds and biocompatible coatings such as hydroxyapatite and bioactive glass are required to isolate the implant, protect the zone from the metallic, ionic exchange, and enhance the bone regeneration by mimicking the composition and structure of the body, thus enhancing cell proliferation. The materials can be further functionalized with growth factors that create a better response and higher chances of success for clinical use. This review highlights the vast majority of newly obtained information regarding bone tissue engineering, such as new co-culturing models, implant coatings, scaffolds, biomolecules, and the techniques utilized to obtain them.

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Section: Hydroxyapatite For Btementioning

confidence: 99%

Bone Regeneration and Oxidative Stress: An Updated Overview

et al. 2022

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“…BMSCs derived from mesoderm are a type of stem cell with multidirectional differentiation potential. BMSC transplantation, which serves as a representative cell therapy, is becoming prevalent in the field of bone regeneration, cartilage repair, spinal cord injury, and IDD ( Sakai and Andersson, 2015 ; Hejazi et al, 2021 ; Jiang et al, 2021 ; Maldonado-Lasunción et al, 2021 ). However, stem cell therapy still has many limitations such as difficulty in obtaining cells, susceptibility to aging, potential tumorigenesis, and immune rejection, which greatly limit the application in the field of regenerative medicine ( Dou et al, 2021 ).…”

Section: Potential Sources Of Applications By Exosomes During the Pro...mentioning

confidence: 99%

Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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Low back pain (LBP), which is one of the most severe medical and social problems globally, has affected nearly 80% of the population worldwide, and intervertebral disc degeneration (IDD) is a common musculoskeletal disorder that happens to be the primary trigger of LBP. The pathology of IDD is based on the impaired homeostasis of catabolism and anabolism in the extracellular matrix (ECM), uncontrolled activation of immunologic cascades, dysfunction, and loss of nucleus pulposus (NP) cells in addition to dynamic cellular and biochemical alterations in the microenvironment of intervertebral disc (IVD). Currently, the main therapeutic approach regarding IDD is surgical intervention, but it could not considerably cure IDD. Exosomes, extracellular vesicles with a diameter of 30–150 nm, are secreted by various kinds of cell types like stem cells, tumor cells, immune cells, and endothelial cells; the lipid bilayer of the exosomes protects them from ribonuclease degradation and helps improve their biological efficiency in recipient cells. Increasing lines of evidence have reported the promising applications of exosomes in immunological diseases, and regarded exosomes as a potential therapeutic source for IDD. This review focuses on clarifying novel therapies based on exosomes derived from different cell sources and the essential roles of exosomes in regulating IDD, especially the immunologic strategy.

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“…Various preparation methods allow for the construction of different forms of antiosteoporotic CBNMs. The preparation methods discussed here include coprecipitation, ,,,− ,,,− sol–gel, ,− ,,− ,− hydrothermal, ,,, electrochemical deposition, ,, electrostatic spray deposition, vapor diffusion, sonochemical synthesis, and physical crushing. − Each preparation method has unique advantages and is accordingly suitable for the preparation of specific forms of CBNMs. The physicochemical properties of CBNMs prepared by different methods are summarized in Table .…”

Section: Cbnms For Osteoporosis Treatmentmentioning

confidence: 99%

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

Deng

Wei

Tang

2022

ACS Biomater. Sci. Eng.

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With rapidly aging populations worldwide, osteoporosis has become a serious global public health problem. Caused by disordered systemic bone remodeling, osteoporosis manifests as progressive loss of bone mass and microarchitectural deterioration of bone tissue, increasing the risk of fractures and eventually leading to osteoporotic fragility fractures. As fracture risk increases, antiosteoporosis treatments transition from nonpharmacological management to pharmacological intervention, and finally to the treatment of fragility fractures. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment because of several characteristics including similarity to natural bone, excellent biocompatibility, easy preparation and functionalization, low pH-responsive disaggregation, and inherent pro-osteogenic properties. By combining additional ingredients, CBNMs can play multiple roles to construct antiosteoporotic biomaterials with different forms. This review covers recent advances in CBNMs for osteoporosis treatment. For ease of understanding, CBNMs for antiosteoporosis treatment can be classified as locally applied CBNMs, such as implant coatings and filling materials for osteoporotic bone regeneration, and systemically administered CBNMs for antiosteoporosis treatment. Locally applied CBNMs for osteoporotic bone regeneration develop faster than the systemically administered CBNMs, an important consideration given the serious outcomes of fragility fractures. Nevertheless, many innovations in construction strategies and preparation methods have been applied to build systemically administered CBNMs. Furthermore, with increasing interest in delaying osteoporosis progression and avoiding fragility fracture occurrence, research into systemic administration of CBNMs for antiosteoporosis treatment will have more development prospects. Deep understanding of the CBNM preparation process and optimizing CBNM properties will allow for increased application of CBNMs in osteoporosis treatments in the future.

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Improved healing of critical-size femoral defect in osteoporosis rat models using 3D elastin/polycaprolactone/nHA scaffold in combination with mesenchymal stem cells

Cited by 14 publications

References 32 publications

Bone Regeneration and Oxidative Stress: An Updated Overview

Bone Regeneration and Oxidative Stress: An Updated Overview

Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration

Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment

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