Improved functionality and safety of peptides by the formation of peptide-polyphenol complexes

Comparison of characteristics and antioxidant activities of sesame protein hydrolysates and their fractions

“…Extensive research has identified sesame as a rich source of bioactive compounds, notably polyphenols and bioactive peptides. These polyphenols, including sesamin, sesamolin, and sesamol, are renowned for their potent antioxidant properties, which confer cellular protection against oxidative stress, while also manifesting anti-inflammatory and anticancer effects [ 27 , 31 ]. In parallel, bioactive peptides derived from sesame protein hydrolysates have been shown to exhibit a range of beneficial activities, encompassing antioxidant effects, ACE inhibition, and anti-inflammatory properties [ 32 ].…”

Glutamine‐derived peptides: Current progress and future directions

“…This is due to the high levels of glutamine which enable the peptides to evade digestion in the gastrointestinal tract and instead interact directly with the small intestinal mucosa. This interaction promotes the release of IL-8 and IL-15, ultimately contributing to the development of inflammatory bowel disease (IBD) (Lin et al, 2023). A typical example is that gluten peptide (Gly-Gln-Gln-Gln-Pro-Phe-Pro-Pro-Gln-Pro-Tyr-Pro-Gln-Pro-Gln-Pro-Phe-Pro-Pro-Pro) is highly resistant to protease degradation, which is concerning due to its immunotoxin properties, which have the potential to contribute to the development of CD (Palanski et al, 2022).…”

“…To mitigate the potential food safety risk associated with glutamine-rich protein hydrolysis products, studies have shown that the safety of peptides can be enhanced by inhibiting the adsorption of these gluten peptides to cellular epitopes. This can be achieved with the assistance of polyphenols, which can mask the epitopes or alter the relevant structure of the peptide (Lin et al, 2023). Moreover, it is imperative to conduct a simulation of the protein digestion process and evaluate the type and quantity of peptides produced before scaling up production.…”