Improved frozen section examination of the retroareolar margin for prediction of nipple involvement in breast cancer

Piato, José Roberto Morales; Aguiar, Fernando Nalesso; Mota, Bruna Salani; Ricci, Marcos Desídérío; Dória, Maíra Teixeira; Alves-Jales, RD; Messias, A.P.; Filassi, José Roberto; Baracat, E.C.

doi:10.1016/j.ejso.2015.04.019

Cited by 17 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study on imprint cytological assessment of the subareolar tissue showed that it might not be sufficient as an exclusive method for the intraoperative assessment of the NAC, having the sensitivity of 50% and the specificity of 87.58% [ 36 ]. The intraoperative assessment of NAC by frozen sections is more sensitive (92%), but to obtain reliable results it is needed to use specific diagnostic protocols [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients

et al. 2017

View full text Add to dashboard Cite

BackgroundThe role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the association between malignant NDc and nipple malignancy.MethodsWe retrospectively analyzed a case series of 139 patients with NDc who underwent breast surgery. The clinical and histological findings, types of surgery with emphasis on nipple-areola complex amputation, immunohistochemical phenotypes of the carcinomas and measurements of the tumor-nipple distance were recorded. Additionally, in patients who showed HER2-positive lesions on definitive surgery, we evaluated the HER2 immunocytochemistry of the NDc smears.ResultsThirty-two malignant and 107 benign/borderline NDc diagnoses were identified. All 32 malignant-NDc cases were histologically confirmed as malignant. Thirty borderline/benign-NDc cases were histologically diagnosed as malignant (sensitivity 58%). The majority of the patients with malignant NDc were treated with nipple-areola complex amputations in both the mastectomy and conservative surgery groups (P<0.001, χ251.77). Nipple involvement was strongly associated with HER2-positive ductal carcinoma in-situ (P<0.001, χ211.98). HER2 immunocytochemistry on the NDc revealed a 100% correlation with the immunocytochemistry performed on the surgical tissues.ConclusionsMalignant NDc influenced surgical management. The association of malignant NDc with nipple involvement is highly related to ductal carcinoma in-situ with HER2 overexpression. In case of HER2 positive NDc, nipple-areola complex involvement is more likely than in HER2 negative cases.

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Studies involving expressive cohorts showed that the subareolar frozen-section examination could yield false-negative rates between 1.3% and 9.3% [1,[20][21][22]. Even with the very favorable results shown with this technique, its use is limited because of the complexity of the method involved.…”

Section: Discussionmentioning

confidence: 99%

MRI to Predict Nipple Involvement in Breast Cancer Patients

Piato

Andrade

Chala

et al. 2016

American Journal of Roentgenology

View full text Add to dashboard Cite

show abstract

“…Although the distance of tumor to nipple has been shown to correlate with likelihood of nipple involvement, some patients with tumors close to but not involving the nipple are now being offered this procedure (175). There is also controversy as to whether intraoperative evaluation can accurately identify nipple involvement for which further surgery is warranted, or whether permanent pathology is most accurate (176). Nipple involvement with malignancy (DCIS, invasive ductal cancer, invasive lobular cancer) should be treated with excision.…”

Section: Expanding Indications For Nipple-sparing Mastectomymentioning

confidence: 99%

Trends and controversies in multidisciplinary care of the patient with breast cancer

Dominici

Morrow

Mittendorf

et al. 2016

Current Problems in Surgery

View full text Add to dashboard Cite

Improved frozen section examination of the retroareolar margin for prediction of nipple involvement in breast cancer

Cited by 17 publications

References 23 publications

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients

MRI to Predict Nipple Involvement in Breast Cancer Patients

Trends and controversies in multidisciplinary care of the patient with breast cancer

Contact Info

Product

Resources

About