Improved executive functioning following repetitive transcranial magnetic stimulation

Moser, David J.; Jorge, Ricardo E.; Manes, Facundo; Paradiso, Sergio; Benjamin, Michelle; Robinson, Robert G.

doi:10.1212/wnl.58.8.1288

Cited by 133 publications

(97 citation statements)

References 10 publications

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“…Several randomized, sham-controlled trials designated to investigate the antidepressant efficacy of rTMS also reported interesting findings regarding the effects of rTMS on cognitive performance [12,23,24,25,26,27,28,29,30,31,32,33,34]. However, given the limited availability of neurocognitive measures and the open nature of most available studies, to what extent rTMS may be really beneficial on neurocognitive performance is still unknown.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Performance in Treatment-Resistant Depression. A Systematic Review

et al. 2015

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Background: Major depressive disorder (MDD) is a disabling illness associated with significant functional and psychosocial impairment. Although many psychopharmacological agents are currently available for its treatment, many MDD patients suffer from treatment-resistant depression (TRD). Methods: A systematic review of the current literature (Pubmed/Medline, Scopus and ScienceDirect search) has been conducted with the primary aim to investigate the role of repetitive transcranial magnetic stimulation (rTMS) in improving neurocognition in patients with TRD. Studies were included according to the following criteria: (a) being an original paper in a peer-reviewed journal and (b) having analyzed the effect of rTMS on neurocognitive functioning in TRD. Results: The combined search strategy yielded a total of 91 articles, of which, after a complete analysis, 22 fulfilled our inclusion criteria. Based on the main findings, most of the selected studies suggested the existence of a trend towards improvements in the neurocognitive profile using rTMS. Negative findings have also been reported. However, most studies were limited by their small sample size or included mixed samples, or the adopted single-blind designs potentially biased the blinding of the study design. Conclusion: rTMS is a noninvasive brain stimulation that may be considered a valuable and promising technique for cognitive enhancement in TRD.

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Section: Introductionmentioning

confidence: 99%

The Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Performance in Treatment-Resistant Depression. A Systematic Review

et al. 2015

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“…Mild and few adverse effects such as headache were reported [131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148][149] . Another advantage of the use of rTMS is the improvement in executive functions by rTMS 150,151 . Preliminary data suggests that better responses to magnetic stimulation are obtained in patients with higher frontal volumes.…”

Section: Mdd In the Rehabilitation Settingmentioning

confidence: 99%

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Brunoni

Teng

Correa³

et al. 2010

Arq. Neuro-Psiquiatr.

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The use of neuromodulation as a treatment for major depressive disorder (MDD) has recently attracted renewed interest due to development of other non-pharmacological therapies besides electroconvulsive therapy (ECT) such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS). Method: We convened a working group of researchers to discuss the updates and key challenges of neuromodulation use for the treatment of MDD. results: The state-of-art of neuromodulation techniques was reviewed and discussed in four sections: [1] epidemiology and pathophysiology of MDD; [2] a comprehensive overview of the neuromodulation techniques; [3] using neuromodulation techniques in MDD associated with non-psychiatric conditions; [4] the main challenges of neuromodulation research and alternatives to overcome them. Discussion: ECT is the first-line treatment for severe depression. TMS and tDCS are strategies with a relative benign profile of side effects; however, while TMS effects are comparable to antidepressant drugs for treating MDD; further research is needed to establish the role of tDCS. DBS and VNS are invasive strategies with a possible role in treatment-resistant depression. In summary, MDD is a chronic and incapacitating condition with a high prevalence; therefore clinicians should consider all the treatment options including invasive and non-invasive neuromodulation approaches. Key words: comprehensive review, major depressive disorder, ECT, TMS, clinical guidelines.Estratégias de neuromodulação para o tratamento da depressão maior: desafios e recomendações de uma força-tarefa rEsuMo O uso de técnicas de neuromodulação para o tratamento do transtorno depressivo maior (TDM) tem despertado um renovado interesse nos últimos anos com o desenvolvimento de outras intervenções não-farmacólogicas além da eletroconvulsoterapia (ECT), como a estimulação magnética transcraniana (EMT), a estimulação transcraniana por corrente continua (ETCC), a estimulação cerebral profunda (DBS) e a estimulação de nervo vago (VNS). Método: Nós organizamos um grupo de trabalho com vários pesquisadores para discutir os avanços recentes e os principais desafios para o uso da neuromodulação no tratamento os principais desafios da pesquisa na neuromodulação e alternativas para superá-los. Discussão: ECT é o tratamento de primeira linha para depressão grave. EMT e ETCC são estratégias com um perfil benigno de efeitos adversos; contudo, enquanto os efeitos da EMT são comparáveis ao das drogas antidepressivas para o tratamento da TDM, a eficácia da ETCC ainda precisa ser estabelecida por mais pesquisas clínicas. DBS e VNS são intervenções invasivas com um papel possível para a depressão refratária. Em resumo, TDM é uma condição crônica, incapacitante e de alta prevalência; portanto na prática clínica todas as opções de tratamento possíveis, incluindo as farmacológicas e não-farmacológicas, devem ser consideradas. Palavras-chave: artigo de revisão, tra...

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“…36 Na bateria neuropsicológica utilizada foram empregados testes relacionados às funções de memória (teste de aprendizado verbal auditivo de Rey), executivas (Trail Making, teste de Stroop, Dígitos, Fluência Verbal), visuoespaciais (julgamento de orientação de linhas) e linguagem (teste de nomeação de Boston). Esse estudo encontrou uma melhora significativa no desempenho dos pacientes na parte B do teste Trail Making, sugerindo a possibilidade de a EMTr melhorar aspectos do funcionamento executivo independentemente de alterações do quadro depressivo -avaliado pela escala de depressão Hamilton (HDRS) -ou do funcionamento cognitivo geral.…”

Section: -40unclassified

Estimulação magnética transcraniana na neuropsicologia: novos horizontes em pesquisa sobre o cérebro

Boggio

Fregni

Rigonatti

et al. 2006

Rev. Bras. Psiquiatr.

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Estimulação magnética transcraniana na neuropsicologia: novos horizontes em pesquisa sobre o cérebro Transcranial magnetic stimulation in neuropsychology:new horizons for brain research ResumoEsta revisão discute o uso da estimulação magnética transcraniana como ferramenta de pesquisa das funções neuropsicológicas. A estimulação magnética transcraniana é uma técnica não-invasiva e praticamente indolor em seres humanos conscientes, baseada em um campo magnético variável. Tal técnica possibilita a geração, em pessoas saudáveis, de lesões temporárias virtuais ou, também, de aumento da atividade das áreas estimuladas, permitindo o estudo do comportamento e da cognição de maneira mais estruturada e precisa. Nesta revisão são apresentados trabalhos com estimulação magnética transcraniana nos quais foram estudados aspectos da linguagem, memória e baterias neuropsicológicas em protocolos de pesquisa clínica. Conclui-se que estudos com estimulação magnética transcraniana abrem novas perspectivas e possibilidades no campo da Neuropsicologia na medida em que fornecem elementos para o aprofundamento do conhecimento sobre as correlações entre cognição e córtex.Descritores: Neuropsicologia; Estimulação magnética; Manifestações neurocomportamentais; Tratamento; Modulação cortical A b s t r a c tThis review addresses the use of transcranial magnetic stimulation as a research tool of neuropsychological functions. Transcranial magnetic stimulation is a non-invasive and painless technique to modulate brain function that can be applied to conscious human beings and is based on a variable magnetic field. Using this technique, it is possible to generate virtual transient lesions in healthy people or modulate the brain activity, increasing or decreasing the activity of the stimulated areas. In this review we discuss studies with transcranial magnetic stimulation in which broad aspects of language, memory and neuropsychological tests have been evaluated following or during the application of transcranial magnetic stimulation. We concluded that transcranial magnetic stimulation open new horizons for brain research in the neuropsychological field as transcranial magnetic stimulation allows the investigation of the relationship between focal cortical activity and behavior therefore contributing to the study of the functional brain activity.

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Improved executive functioning following repetitive transcranial magnetic stimulation

Cited by 133 publications

References 10 publications

The Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Performance in Treatment-Resistant Depression. A Systematic Review

The Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Performance in Treatment-Resistant Depression. A Systematic Review

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Estimulação magnética transcraniana na neuropsicologia: novos horizontes em pesquisa sobre o cérebro

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