Improved Endothelialisation on Nanostructured Surfaces

Aktas, Cenk; Haidar, Ayman; Miró, Marina Martinez; Dörrschuck, E.; Lee, Juseok; Veith, Michael; Khaliq, H Abdul

doi:10.4028/www.scientific.net/amr.324.105

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…The decrease in cell viabilities and populations can be explained by the difference in the surface topography induced by the deposited 1D Al 2 O 3 nanostructures [ 18 , 19 ]. However, overcoating of 1D Al 2 O 3 nanostructures with re-phages led to a clear increase in cell populations and viabilities around 40% and 30%, respectively, as compared to 1D Al 2 O 3 nanostructures.…”

Section: Resultsmentioning

confidence: 99%

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Lee

Jeon

Haidar

et al. 2015

BioMed Research International

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A novel synthesis of a nanostructured cell adhesive surface is investigated for future stent developments. One-dimensional (1D) Al2O3 nanostructures were prepared by chemical vapor deposition of a single source precursor. Afterwards, recombinant filamentous bacteriophages which display a short binding motif with a cell adhesive peptide (RGD) on p3 and p8 proteins were immobilized on these 1D Al2O3 nanostructures by a simple dip-coating process to study the cellular response of human endothelial EA hy.926. While the cell density decreased on as-deposited 1D Al2O3 nanostructures, we observed enhanced cell proliferation and cell-cell interaction on recombinant phage overcoated 1D Al2O3 nanostructures. The recombinant phage overcoating also supports an isotropic cell spreading rather than elongated cell morphology as we observed on as-deposited Al2O3 1D nanostructures.

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Section: Resultsmentioning

confidence: 99%

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Lee

Jeon

Haidar

et al. 2015

BioMed Research International

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“…Our results showed that there is a preference of HUVEC adhesion on nanowires in comparison to that of HUVSMC. 71 The control of the cell-surface interaction by the topography may represent a key issue for the future stent material design.…”

Section: Implants and Bioactive Surfaces With Al/al 2 O 3 Nanostructuresmentioning

confidence: 99%

Bi-phasic nanostructures for functional applications

et al. 2012

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Biphasic solid state composites of the type metal/metal oxide or element/element oxide can be synthesized in one pot chemical reactions using so called molecular "single source precursors". Due to their singular genesis these composites show peculiar hetero-structures based on core-shell hierarchies such as superlattices and composite nanospheres or nanowires. They exhibit superior or new functional properties compared to their individual constituent compounds. In the current work, we review in particular the synthetical and mechanistical approach of bi-phasic (Al/Al(2)O(3)) nanostructures such as nanospheres, nanowires and nanoloops using a single source precursor. Other bi-phasic materials of the general formula M/MO(x) (for example M = Ge, Sn, Pb) are addressed for comparison. The impact of different synthetical conditions as well as of modification of surfaces by laser techniques and their technological relevance are presented briefly. Additionally, functional applications of the prepared surfaces are explained with some outstanding case studies. These case studies are primarily concerned with their use as biomaterials and their application in medicine as well as with their use as thin films for optics and functional surfaces.

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“…Previously we have shown the effect of the topography (regardless from the surface chemistry) on the cell adhesion and proliferation using randomly distributed Al 2 O 3 structures prepared by pulsed laser treatment of biphasic Al/Al 2 O 3 nanowires (NWs). Especially surfaces which are composed Al 2 O 3 nano‐ and microstructures seem to improve adhesion and proliferation of normal human dermal fibroblasts (NHDF) . On the other hand in some applications such as targeted re‐innovation, a directional growth of cells is also desired in addition to improved adhesion and proliferation.…”

Section: Introductionmentioning

confidence: 99%

Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires

Lee

Schwarz

Akkan

et al. 2013

Physica Status Solidi (a)

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Modification of topography is an effective tool to control the cellular response such as cell function, adhesion and proliferation on surfaces. In this work, we present a novel method for fabrication of periodic surface structures by laser interference patterning (LIP) of biphasic Al/Al 2 O 3 nanowires (NWs). These structures have a periodicity of 1-8 mm and a depth of 300-600 nm, depending on the incidence angle of the laser beam. Such hierarchical structures are composed of both micro-and nanofeatures. These periodic patterns lead to an alignment of glial cells and an axonal guidance from cultured dorsal root ganglia (DRG), along defined directions. The most pronounced alignment was seen at a periodicity of 2 mm.(a) Random growth of neurites on as-deposited chaotic NWs. (b) Aligned growth of neurites on patterned NWs.

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Improved Endothelialisation on Nanostructured Surfaces

Cited by 9 publications

References 13 publications

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Bi-phasic nanostructures for functional applications

Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires

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Improved Endothelialisation on Nanostructured Surfaces

Cited by 9 publications

References 13 publications

Recombinant Phage Coated 1D Al2O3Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Recombinant Phage Coated 1D Al2O3Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Bi-phasic nanostructures for functional applications

Guidance of glial cells and neurites from dorsal root ganglia by laser induced periodic patterning of biphasic core/shell nanowires

Contact Info

Product

Resources

About

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells

Recombinant Phage Coated 1D Al₂O₃Nanostructures for Controlling the Adhesion and Proliferation of Endothelial Cells