Improved Electron-Capture GLC Determination of Alprenolol and Oxprenolol in Serum Using a Wall-Coated Open Tubular Column

Debruyne, Danièle; Kinsun, H.; Moulin, Maryline; Bigot, M.-C.

doi:10.1002/jps.2600680433

Cited by 23 publications

(2 citation statements)

References 18 publications

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“…In addition, other experimentsg with 11-1-75 particles showed that polyacryldextran was metabolized more rapidly in uitro with rat liver homogenates and also was eliminated faster in uiuo after intraperitoneal injection in mice than in the cases involving polyacrylamide (T-C value of [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. These findings were expected since dextran should be degraded easier in uiuo than hydrocarbon chains, the content of which is comparatively small in polyacryldextran particles with D-T-C values of 11-1-75.…”

Section: Discussionmentioning

confidence: 99%

Immobilization of proteins in microspheres of biodegradable polyacryldextran

Edman

Ekman

Sjöholm

1980

Journal of Pharmaceutical Sciences

155

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Section: Discussionmentioning

confidence: 99%

Immobilization of proteins in microspheres of biodegradable polyacryldextran

Edman

Ekman

Sjöholm

1980

Journal of Pharmaceutical Sciences

155

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“…The *Hg analog is employed as the internal DeBruyne eta/. [67] have employed capillary column GLC with ECD of the HFB derivatives for the determination of two other P-blockers, alprenolol and oxprenolol, in serum (0.1 to 0.2 ml). These authors report that switching from packed column GLC to capillary column GLC markedly increased the sensitivity of their assay.…”

Section: 4-(oh) 2 Bmentioning

confidence: 99%

Analysis of drugs and related compounds by capillary column GLC

Vandenheuvel

Zweig

1980

J. High Resol. Chromatogr.

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SummaryThis article describes the development of the application of capillary column GLC methods to steroids, prostaglandins and especially drugs and their metabolites in samples of biological origin. The wide variety -in terms of structures and pharmacological properties -of drugs now analyzed by capillary column GLC is made evident. Reasons for use of capillary rather than packed columns are given. The frequent use of and need for derivatization procedures prior to chromatography is emphasized. A bibliography of 83 references is included in the manuscript.

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Simultaneous determination of oxprenolol and2H6-labelled oxprenolol in human plasma by gas chromatography/mass spectrometry

Gaudry¹,

Wantiez²,

Metayer³

et al. 1985

Biol. Mass Spectrom.

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A gas chromatographic/mass spectrometric method for the specific determination of oxprenolol and 2H6-labelled oxprenolol when both are present in the same sample is described. After addition of 13C3-labelled oxprenolol as internal standard, plasma is alkalized and extracted by a mixture of dichloromethane and diethyl ether. The residue following evaporation of the organic phase is derivatized with heptafluorobutyric anhydride. Negative ion detection with N2O as reagent gas is used for the measurements at m/z 488, 491 and 494 for oxprenolol, the 13C3-labelled internal standard and 2H6-labelled oxprenolol, respectively. The precision and accuracy of the analytical method were investigated using samples containing both unlabelled and 2H6-labelled oxprenolol. The overall mean recovery (% +/- SD, n = 70) in the concentration range 20-1500 nmol l-1 (around 6-450 ng ml-1 of the hydrochloride salts) was 100.6 +/- 3.3 and 101.0 +/- 3.5 for oxprenolol and 2H6-labelled oxprenolol, respectively. The limit of quantification was around 20 nmol l-1 for both compounds.

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Improved Electron-Capture GLC Determination of Alprenolol and Oxprenolol in Serum Using a Wall-Coated Open Tubular Column

Cited by 23 publications

References 18 publications

Immobilization of proteins in microspheres of biodegradable polyacryldextran

Immobilization of proteins in microspheres of biodegradable polyacryldextran

Analysis of drugs and related compounds by capillary column GLC

Simultaneous determination of oxprenolol and2H6-labelled oxprenolol in human plasma by gas chromatography/mass spectrometry

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