Improved Electrochemical Peptide Synthesis Enabled by Electron‐Rich Triaryl Phosphines
Shingo Shinjo‐Nagahara,
Yohei Okada,
Goki Hiratsuka
et al.
Abstract:While remarkable progress has been made in the development of peptide medicines, many problems related to peptide synthesis remain unresolved. Previously, we reported electrochemical peptide synthesis using a phosphine as a potentially recyclable coupling reagent. However, there was room for improvement from the point of view of reaction efficiency, especially in the carboxylic acid activation step and the peptide bond formation step. To overcome these challenges, we searched for the optimal phosphine. Among p… Show more
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