Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

Abstract

Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration. We tested the performance of the new PSO delivery system in animal models for impaired memory and locomotor activity. The experimental results indicated a statistically significant improvement (p < 0.05) of more than 1.5 fold in the behavior of animals treated nasally, in comparison to those treated with orally administrated oil. Furthermore, in multiphoton microscopy and near infrared imaging studies, the nasal administration of fluorescent probes, fluorescein isothiocyanate (FITC), and indocyanine green (ICG) incorporated in the PSO system showed enhanced delivery to the brain. Results of the histopathologic examination of the nasal cavity and mucosa, as carried out by a pathologist, indicated the safety of the PSO phospholipid oily gel. In conclusion, the results of this work encourage further investigation of the phospholipid oily gel composition as a new way of PSO administration.

Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis

“…Auerbach et al also reported changes in estradiol, FSH, luteinizing hormone (LH), prolactin, progesterone, testosterone, and thyroid‐stimulating hormone (Natsheh & Touitou, 2022) in their study after 12 weeks of PSO consumption. Detected changes between the two groups were not significant in any of the parameters.…”

“…In the study by Kapoor et al (2015) (Natsheh & Touitou, 2022) in their study after 12 weeks of PSO consumption. Detected changes between the two groups were not significant in any of the parameters.…”

Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

“…The oil composition of pomegranate seed has lately garnered special attention due to its abundance of antioxidant and anticancer compounds, which might be key components in the development of novel treatments and cosmetics. Because of its nutritional and therapeutic characteristics, pomegranate seed oil is utilized as a functional component in the food, pharmaceutical, and feed sectors. , PSO is a rich source of poly- and monounsaturated fatty acids, which explains its antioxidant, anti-inflammatory, and neuroprotective activities. , The combination of PSO and ketoprofen in the self-nanoemulsifying system is suggested to enhance the therapeutic effect of the drug. Further in vivo pharmacodynamic studies are required to assess the anti-inflammatory and analgesic effects of this promising combination.…”

“…29,30 PSO is a rich source of poly-and monounsaturated fatty acids, which explains its antioxidant, anti-inflammatory, and neuroprotective activities. 31,32 The combination of PSO and ketoprofen in the self-nanoemulsifying system is suggested to enhance the therapeutic effect of the drug. Further in vivo pharmacodynamic studies are required to assess the anti-inflammatory and analgesic effects of this promising combination.…”

Evaluating the Neuroprotective Potential of Novel Benzodioxole Derivatives in Parkinson’s Disease via AMPA Receptor Modulation

“…The number of crossed squares was counted during 5 min with no habituation session. Animals treated with effective neuroprotective drugs are expected to cross more squares. , …”