Improved early prediction of pre‐eclampsia by combining second‐trimester maternal serum inhibin‐A and uterine artery Doppler

Aquilina, J.; Thompson, Olaleye; Thilaganathan, B.; Harrington, Kevin

doi:10.1046/j.1469-0705.2001.00382.x

Cited by 85 publications

(50 citation statements)

References 24 publications

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“…Cases of gestational hypertension without proteinuria are shown as circles, cases of preeclampsia as triangles. Prefumo It has been suggested that-in analogy to screening strategies for trisomy 21 (12)-the combination of multiple Doppler or maternal serum markers may allow better prediction capabilities (10,11,21,22). Combining different first-trimester Doppler and maternal serum markers could therefore improve our capabilities of identifying high-risk pregnancies early enough to reduce the risk of complications.…”

Section: Figurementioning

confidence: 98%

Correlation between first-trimester uterine artery Doppler indices and maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A

Prefumo

Canini²,

Casagrande

et al. 2006

Fertility and Sterility

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Section: Figurementioning

confidence: 98%

Correlation between first-trimester uterine artery Doppler indices and maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A

Prefumo

Canini²,

Casagrande

et al. 2006

Fertility and Sterility

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“…On the basis of published evidence [36] , if trials are performed to determine the real potential of therapies such as aspirin, calcium, or others, a screening test done during the fi rst half of pregnancy with a high sensitivity and high PPV ( 1 40%) and PLR ( 1 12) is essential. Therefore, if our results are confi rmed in larger studies, the combination of tHcy and uterine artery Doppler would appear to satisfy the criteria of an effective early method for predicting preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Combining 2nd-Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Isolated Intrauterine Growth Restriction

Önalan¹,

Önalan²,

Gunenc

et al. 2006

Gynecol Obstet Invest

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Aim: To evaluate the efficacy of a combined 2nd-trimester maternal serum homocysteine and uterine artery Doppler screening at 20 weeks of gestation for complications of pregnancy: preeclampsia, isolated intrauterine growth restriction (IUGR), placental abruption, and stillbirths. Methods: Consecutive singleton pregnancies without previous risk factors who had homocysteine measured as part of a serum-screening program for trisomy 21 had uterine artery Doppler performed. Sensitivity, specificity, positive and negative predictive values, odds ratio, and positive and negative likelihood ratios for the subsequent development of preeclampsia, isolated IUGR, placental abruption, stillbirth, and preterm delivery were calculated for the following methods (1) homocysteine cutoff level 6.3 µmol/l (95th centile); (2) on Doppler ultrasound bilateral notches with a mean resistance index (RI) >0.55 (50th centile), all unilateral notches with a mean RI >0.65 (80th centile), and absence of notches with a mean RI >0.7 (95th centile), and (3) Doppler ultrasound notch evaluation (bilateral, unilateral, absence as in method 2) combined with the homocysteine cutof level of 6.3 µmol/l. Results: By using a logistic regression model, methods 1 and 2 predicted preeclampsia (p < 0.001), isolated IUGR (p < 0.01), and ‘any complication’ (p < 0.01). The sensitivity for prediction of preeclampsia using the combined method (3) was 61.3% for a false-positive rate of 2%, better than that for isolated IUGR (54%) below the 5th centile and ‘any complication’(56%). Conclusion: This prospective study confirms the potential of a combined method of elevated homocysteine and uterine artery Doppler screening for preeclampsia, isolated IUGR, and any obstetric complication.

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“…While low PAPP-A or hCG in the first trimester [31][32][33] or increased serum AFP, hCG, or inhibin-A in the second trimester [34][35][36] are associated with an increased risk of placentarelated diseases and early onset preeclampsia and IUGR, predictive values do not currently support routine use. Similarly, uterine artery Doppler can identify pregnancies at risk 37 but is not recommended for general application.…”

Section: Early Pregnancy Predictionmentioning

confidence: 89%

Clinical Strategies for Improving the Detection of Fetal Growth Restriction

Gardosi¹

2011

Clinics in Perinatology

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Improved early prediction of pre‐eclampsia by combining second‐trimester maternal serum inhibin‐A and uterine artery Doppler

Cited by 85 publications

References 24 publications

Correlation between first-trimester uterine artery Doppler indices and maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A

Correlation between first-trimester uterine artery Doppler indices and maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A

Combining 2nd-Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Isolated Intrauterine Growth Restriction

Clinical Strategies for Improving the Detection of Fetal Growth Restriction

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