Improved early bone-implant integration in transgenic mice overexpressing bovine growth hormone

Abstract

Titanium implants were inserted in transgenic mice overexpressing bovine growth hormone. Four weeks after insertion the implants were cut out en blocwith the surrounding bone. The undecalcified specimens were cut and ground to a thickness of approximately 10 I~m. Histomorphometry demonstrated significantly more direct bone to metal contact for the transgenic mice than for the non-transgenic littermates. The results indicate that endogenous high levels of bovine growth hormone result in improved early bone-implant integration. This study indicate that it may be possible to systemically administrate growth hormone in man, in the early healing in phase, to improve implant integration.

Surface contaminants inhibit osseointegration in a novel murine model

“…Second, it will allow for cost effective screening of potential countermeasures for impaired osseointegration prior to testing in larger animals. Two laboratories reported preliminary osseointegration studies in mice in the mid-1990s [51,52,53]. Recently, osseointegration studies in mice have demonstrated that molecular pathways known to regulate bone turnover also affect osseointegration.…”